Shi Yunhao, Yin Jiajia, Peng Qinqin, Lv Xinyi, Li Qinzhe, Yang Dongliang, Song Xuejiao, Wang Wenjun, Dong Xiaochen
Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) & Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an 710072, China.
Biomater Sci. 2020 Nov 7;8(21):6093-6099. doi: 10.1039/d0bm01165g. Epub 2020 Oct 1.
Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic antibacterial therapy in the second near-infrared (NIR) region. The POM can self-assemble into larger-sized aggregates with stronger absorption in the NIR region, making it remain in the acidic infected tissue. Furthermore, the hydrogen peroxide at the site of infection can be converted to a hydroxyl radical for chemodynamic therapy (CDT) and simultaneously the glutathione in organisms is consumed by the POM to further enhance the CDT effect. More importantly, under laser irradiation, the hyperthermia produced by the POM not only can kill drug-resistant Staphylococcus aureus, but also enhance the performance of CDT. Benefitting from the inflammatory retention and acidity-responsive photothermal-enhanced CDT properties, the POM exhibits an obvious therapeutic effect against drug-resistant bacterial infection without significant side effects under 1060 nm laser irradiation.
由耐药病原体引起的皮下脓肿对人类健康构成了严峻挑战。为克服这一问题，本文开发了一种酸度响应性聚集的钨/钼基多金属氧酸盐（POM），用于在第二近红外（NIR）区域进行光热增强化学动力学抗菌治疗。该POM能自组装成尺寸更大的聚集体，在近红外区域具有更强的吸收，使其能留在酸性感染组织中。此外，感染部位的过氧化氢可转化为羟基自由基用于化学动力学疗法（CDT），同时生物体中的谷胱甘肽被POM消耗，以进一步增强CDT效果。更重要的是，在激光照射下，POM产生的热疗不仅能杀死耐药金黄色葡萄球菌，还能增强CDT性能。得益于炎症滞留和酸度响应性光热增强CDT特性，POM在1060 nm激光照射下对耐药细菌感染表现出明显的治疗效果，且无明显副作用。
