Lund University, Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Sweden.
Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Contact Dermatitis. 2021 Mar;84(3):153-158. doi: 10.1111/cod.13710. Epub 2020 Oct 22.
In Sweden, cobalt chloride 0.5% has been included in the baseline series since the mid-1980s. A recent study from Stockholm showed that cobalt chloride 1% petrolatum (pet.) was more suitable than 0.5%. Cobalt chloride at 1.0% has been patch tested for decades in many European countries and around the world.
To study the suitability of patch testing to cobalt 1.0% vs 0.5% and to analyze the co-occurrence of allergy to cobalt, chromium, and nickel.
Contact allergy to cobalt was shown in 90 patients (6.6%). Eighty (5.9%) patients tested positive to cobalt 1.0%. Thirty-seven of the 90 patients (41.1%) with cobalt allergy were missed by cobalt 0.5% and 10 (0.7%) were missed by cobalt 1.0% (P < .001). No case of patch test sensitization was reported. Allergy to chromium was seen in 2.6% and allergy to nickel in 13.3%. Solitary allergy to cobalt without nickel allergy was shown in 61.1% of cobalt-positive individuals. Female patients had larger proportions of positive reactions to cobalt (P = .036) and nickel (P < .001) than males.
The results speak in favor of replacing cobalt chloride 0.5% with cobalt chloride 1.0% pet. in the Swedish baseline series, which will be done 2021.
自 20 世纪 80 年代中期以来，瑞典的基线系列中就包含了 0.5%的氯化钴。最近来自斯德哥尔摩的一项研究表明，1%的氯化钴凡士林（pet.）比 0.5%更合适。在过去的几十年里，1.0%的氯化钴已经在许多欧洲国家和世界各地进行了斑贴试验。
研究 1.0%氯化钴与 0.5%氯化钴斑贴试验的适用性，并分析钴、铬和镍过敏的同时发生情况。
显示 90 名患者（6.6%）对钴过敏。80 名（5.9%）患者对 1.0%的钴呈阳性。在 90 名有钴过敏的患者中，有 37 名（41.1%）被 0.5%的钴漏检，10 名（0.7%）被 1.0%的钴漏检（P < .001）。没有报告斑贴试验致敏的病例。2.6%的患者对铬过敏，13.3%的患者对镍过敏。61.1%的钴阳性个体表现为单纯钴过敏而无镍过敏。女性患者对钴（P = .036）和镍（P < .001）的阳性反应比例大于男性。
结果表明支持在 2021 年用 1.0%的氯化钴凡士林（pet.）替代瑞典基线系列中的 0.5%的氯化钴。
