Department of Ophthalmology, Vienna Reading Center and OPTIMA Study Group, Medical University of Vienna, Vienna, Austria.
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, China.
Acta Ophthalmol. 2021 Jun;99(4):418-426. doi: 10.1111/aos.14621. Epub 2020 Sep 30.
We aimed to determine the correlation between optical coherence tomography (OCT)- and demographic features and baseline best corrected visual acuity (BCVA) in treatment-naïve patients with retinal vein occlusion (RVO).
This was a cross-sectional posthoc analysis of OCT images that included RVO patients from two prospective, open-label, multicentre studies. The morphological grading was done manually, in the standardized setting of a reading centre. Main outcome measure was the estimated difference in Early Treatment Diabetic Retinopathy Study letters associated with each individual biomarker.
Included were 381/301 treatment-naïve patients with BRVO/CRVO. For BRVO, statistically significant correlations with BCVA were seen for a 100 µm increase in central subfield thickness (CST; -3.1 letters), intraretinal cysts at centre point (CP; +4.1), subretinal fluid (SRF) at CP (+3.0) and hyperreflective foci (HRF) at the central B-scan (-2.2). In CRVO, a 100 µm increase in CST was associated with a loss of -3.4 letters. In the total cohort, 100 µm increase in CST, SRF at CP and HRF at the central B-scan correlated with a difference of -3.2,+3.2 and -2.0 letters. A 10-year increase in age and female gender yielded a -2.0 and -2.5 letter decrease in the total cohort. Adjusted multiple R for the respective group was 18.3%/26.3%/23.5%.
Of all parameters studied, only CST and age were consistently associated with worse BCVA in treatment-naïve RVO patients. Morphology on OCT explained only a modest part of functional loss in this patient cohort.
我们旨在确定光学相干断层扫描（OCT）与人口统计学特征以及未经治疗的视网膜静脉阻塞（RVO）患者的基线最佳矫正视力（BCVA）之间的相关性。
这是对来自两项前瞻性、开放标签、多中心研究的 OCT 图像进行的横断面事后分析。形态学分级是在阅读中心的标准化设置中手动进行的。主要观察指标是与每个个体生物标志物相关的估计的早期治疗糖尿病视网膜病变研究字母差异。
包括 381/301 名未经治疗的 BRVO/CRVO 患者。对于 BRVO，中央子场厚度（CST；-3.1 个字母）、CP 处的视网膜内囊肿（+4.1）、CP 处的视网膜下液（SRF；+3.0）和中央 B 扫描处的高反射焦点（HRF；-2.2）每增加 100µm，与 BCVA 呈显著相关性。对于 CRVO，CST 每增加 100µm，与损失 3.4 个字母相关。在总队列中，CST、CP 处的 SRF 和中央 B 扫描处的 HRF 每增加 100µm，差异分别为-3.2、+3.2 和-2.0 个字母。在总队列中，年龄增加 10 岁和女性性别分别导致 BCVA 下降 2.0 和 2.5 个字母。相应组别的调整后的多重 R 为 18.3%/26.3%/23.5%。
在未经治疗的 RVO 患者中，与所有研究参数相比，只有 CST 和年龄与 BCVA 较差始终相关。OCT 上的形态仅解释了该患者队列中功能丧失的一小部分。
