Department of Ophthalmology, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy.
Invest Ophthalmol Vis Sci. 2021 Nov 1;62(14):1. doi: 10.1167/iovs.62.14.1.
The purpose of this study was to investigate the effects of the extension of collateral vessels on the outcomes of eyes affected by central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO).
The study was designed as a cross-sectional case series. Patients affected by CRVO and BRVO were progressively recruited, along with an age- and sex-matched control group of healthy subjects. Structural optical coherence tomography (OCT) and OCT angiography (OCTA; 4.5 × 4.5 mm and 9.0 × 9.0 mm acquisitions) were performed on all participants in order to assess the relationship between the presence of collateral vessels and final anatomical outcomes - central macular thickness (CMT), foveal avascular zone - and functional outcomes - best corrected visual acuity (BCVA).
Fifty-six eyes affected by CRVO and 47 eyes affected by BRVO were included. Baseline LogMAR BCVA was 0.41 ± 0.33 LogMAR in CRVO, and 0.39 ± 0.25 LogMAR in BRVO (P < 0.01), improving to 0.20 ± 0.26 LogMAR in CRVO (P < 0.01), and 0.19 ± 0.22 LogMAR in BRVO (P < 0.01). Baseline CMT was 511 ± 214 µm in CRVO and 482 ± 178 µm in BRVO (P > 0.05), decreasing to 328 ± 105 µm (P < 0.01) and 321 ± 78 µm in CRVO and BRVO, respectively (P < 0.01). Collateral vessels were detected in 16 of 56 eyes (29%) in CRVO and in 47 of 47 eyes (100%) in BRVO. Their extension was correlated with worse anatomic and visual outcomes. Remarkably, no correlation was found with peripheral capillary nonperfusion and vessel density impairment.
The present study demonstrates that collateral vessel extension is associated with worse anatomic and functional outcomes in patients affected by CRVO and BRVO.
本研究旨在探讨侧支血管的延伸对视网膜中央静脉阻塞（CRVO）和视网膜分支静脉阻塞（BRVO）患者眼部结局的影响。
该研究设计为一项横断面病例系列研究。逐步招募了 CRVO 和 BRVO 患者，并纳入了年龄和性别匹配的健康对照组。对所有参与者进行结构光相干断层扫描（OCT）和 OCT 血管造影（OCTA；4.5×4.5mm 和 9.0×9.0mm 采集），以评估侧支血管的存在与最终解剖结局（中心黄斑厚度[CMT]、无血管区）和功能结局（最佳矫正视力[BCVA]）之间的关系。
纳入了 56 只 CRVO 眼和 47 只 BRVO 眼。CRVO 患者的基线 LogMAR BCVA 为 0.41±0.33LogMAR，BRVO 患者为 0.39±0.25LogMAR（P＜0.01），分别改善至 CRVO 患者的 0.20±0.26LogMAR（P＜0.01）和 BRVO 患者的 0.19±0.22LogMAR（P＜0.01）。CRVO 患者的基线 CMT 为 511±214μm，BRVO 患者为 482±178μm（P＞0.05），分别降低至 328±105μm（P＜0.01）和 321±78μm（P＜0.01）。在 56 只 CRVO 眼中有 16 只（29%）和 47 只 BRVO 眼中有 47 只（100%）检测到侧支血管。它们的延伸与更差的解剖和视力结果相关。值得注意的是，与周边毛细血管无灌注和血管密度损害无相关性。
本研究表明，侧支血管延伸与 CRVO 和 BRVO 患者的解剖和功能结局较差相关。
