Maimónides University, Buenos Aires, Argentina.
Institute of Research in Chemical Sciences, School of Chemical and Technological Sciences, Cuyo Catholic University, San Juan, Argentina.
Am J Physiol Lung Cell Mol Physiol. 2020 Dec 1;319(6):L941-L948. doi: 10.1152/ajplung.00186.2020. Epub 2020 Sep 30.
The COVID-19 pandemic has reached most of the countries worldwide causing death, which often results from an inflammatory storm associated with severe acute respiratory syndrome (SARS). This has prompted researchers to seek specific novel and definitive treatments urgently. In this context, it is interesting to evaluate the preventive and therapeutic effects of existing pharmacological agents that could be useful. In this regard, vitamin D supplementation, particularly in individuals likely to be deficient, may be a promising option. Vitamin D is a hormone that modulates many of the same inflammatory and oxidative signaling pathways triggered during COVID-19. For example, vitamin D suppresses the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response related to COVID-19. This paper analyzes the evidence that vitamin D supplementation might be a valuable preventive/therapeutic measure in groups at risk for or infected with COVID-19. It also discusses how clinical studies could be best designed to evaluate the possible advantages of vitamin D supplementation for the benefit of public health during the pandemic.
新型冠状病毒肺炎（COVID-19）已在全球大部分国家蔓延，导致许多人死亡，而炎症风暴往往是导致严重急性呼吸综合征（SARS）的原因。这促使研究人员迫切寻求特定的新型和明确的治疗方法。在这种情况下，评估现有药理学药物的预防和治疗效果很有意义，这些药物可能会有所帮助。在这方面，维生素 D 的补充，特别是对可能缺乏维生素 D 的个体进行补充，可能是一种很有前景的选择。维生素 D 是一种激素，可调节 COVID-19 期间引发的许多相同的炎症和氧化应激信号通路。例如，维生素 D 可抑制肾素-血管紧张素系统的作用，该系统在与 COVID-19 相关的炎症反应的病理生理学中起决定性作用。本文分析了维生素 D 补充可能是 COVID-19 高危人群或感染者的有价值的预防/治疗措施的证据，并讨论了如何最好地设计临床研究，以评估在大流行期间维生素 D 补充对公共卫生的可能益处。
