Department of Pediatrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
J Int Med Res. 2020 Jun;48(6):300060520926890. doi: 10.1177/0300060520926890.
To assess the effects of a single dose of vitamin D on 25-hydroxyvitamin D (25OHD) levels and clinical outcomes in children with vitamin D deficiency (VDD) and sepsis.
In this randomized, controlled trial, eligible children with VDD and sepsis were assigned to receive one dose of 150,000 IU of cholecalciferol or placebo. Serum concentrations of 25OHD, angiotensin-II (Ang-II), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were assessed at baseline and 8 days after treatment. The cardiovascular Sequential Organ Failure Assessment (cv-SOFA) score, septic shock incidence, duration of ventilation, and mortality were also examined.
One hundred nine participants fulfilled the study requirements. The two groups had comparable baseline characteristics. Ang-II, IL-6, and TNF-α concentrations were all reduced after vitamin D supplementation. Furthermore, the cv-SOFA score (1.76 ± 0.8 vs. 2.3 ± 1.1) and incidence of septic shock (7% vs. 20%) were lower in the treatment group than in the control group. The duration of ventilation and mortality rates did not differ between two groups.
A single dose of vitamin D improved 25OHD levels and the incidence of septic shock in children with VDD and sepsis.
评估单次维生素 D 剂量对维生素 D 缺乏（VDD）合并脓毒症患儿 25-羟维生素 D（25OHD）水平和临床结局的影响。
在这项随机对照试验中，符合条件的 VDD 合并脓毒症患儿被随机分为接受 150000IU 胆钙化醇或安慰剂治疗。在基线和治疗 8 天后，评估血清 25OHD、血管紧张素-II（Ang-II）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）浓度。还检查了心血管序贯器官衰竭评估（cv-SOFA）评分、脓毒性休克发生率、通气持续时间和死亡率。
109 名参与者符合研究要求。两组基线特征具有可比性。维生素 D 补充后，Ang-II、IL-6 和 TNF-α浓度均降低。此外，治疗组 cv-SOFA 评分（1.76±0.8 比 2.3±1.1）和脓毒性休克发生率（7%比 20%）均低于对照组。两组通气时间和死亡率无差异。
单次维生素 D 剂量可提高 VDD 合并脓毒症患儿的 25OHD 水平和脓毒性休克发生率。
