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Phenotype and functionality of follicular helper T cells in patients with acute dengue infection.急性登革热感染患者滤泡辅助 T 细胞的表型和功能。
J Biomed Sci. 2020 Apr 8;27(1):50. doi: 10.1186/s12929-020-00641-2.
2
Functional MAIT Cells Are Associated With Reduced Simian-Human Immunodeficiency Virus Infection.功能性 MAIT 细胞与减少的猴免疫缺陷病毒感染相关。
Front Immunol. 2020 Jan 17;10:3053. doi: 10.3389/fimmu.2019.03053. eCollection 2019.
3
Dengue viruses infect human megakaryocytes, with probable clinical consequences.登革热病毒感染人类巨核细胞，可能具有临床后果。
PLoS Negl Trop Dis. 2019 Nov 25;13(11):e0007837. doi: 10.1371/journal.pntd.0007837. eCollection 2019 Nov.
4
Continuation of Dual Antiplatelet Therapy in a Patient with a Coronary Artery Stent with Dengue Hemorrhagic Fever: A Clinical Conundrum.冠心病支架置入术后合并登革出血热患者双联抗血小板治疗的延续：一个临床难题。
Am J Trop Med Hyg. 2020 Jan;102(1):17-19. doi: 10.4269/ajtmh.19-0512.
5
Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients.慢性HIV和/或HCV感染患者中，Vα7.2+CD161++CD8+（黏膜相关恒定T细胞）和Vα7.2+CD161-CD8+ T细胞群受损与肠道微生物群失调之间的关联
Front Microbiol. 2019 Aug 28;10:1972. doi: 10.3389/fmicb.2019.01972. eCollection 2019.
6
Increase of Plasma TNF- Is Associated with Decreased Levels of Blood Platelets in Clinical Dengue Infection.临床登革热感染中，血浆 TNF- 的增加与血小板水平降低有关。
Viral Immunol. 2020 Jan/Feb;33(1):54-60. doi: 10.1089/vim.2019.0100. Epub 2019 Sep 18.
7
T follicular helper cells in human efferent lymph retain lymphoid characteristics.人效应淋巴中的滤泡辅助 T 细胞保留了淋巴样特征。
J Clin Invest. 2019 Jul 2;129(8):3185-3200. doi: 10.1172/JCI125628.
8
Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells.影响人类黏膜相关恒定T细胞功能异质性的因素
Front Immunol. 2018 Jul 10;9:1602. doi: 10.3389/fimmu.2018.01602. eCollection 2018.
9
Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection.生发中心中的 Tfh1 细胞在慢性 HIV/SIV 感染中。
Front Immunol. 2018 Jun 6;9:1272. doi: 10.3389/fimmu.2018.01272. eCollection 2018.
10
Activation of Peripheral T Follicular Helper Cells During Acute Dengue Virus Infection.急性登革病毒感染期间外周滤泡辅助性 T 细胞的激活。
J Infect Dis. 2018 Oct 5;218(10):1675-1685. doi: 10.1093/infdis/jiy360.

外周滤泡辅助性 T 细胞和黏膜相关不变 T 细胞在急性登革热病毒感染的发热期表现出活化表型。

Peripheral Follicular T Helper Cells and Mucosal-Associated Invariant T Cells Represent Activated Phenotypes During the Febrile Phase of Acute Dengue Virus Infection.

机构信息

Infection Biology, Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.

Department of Microbiology, Government Theni Medical College and Hospital, Theni, India.

出版信息

Viral Immunol. 2020 Nov;33(9):610-615. doi: 10.1089/vim.2020.0149. Epub 2020 Sep 30.

DOI:10.1089/vim.2020.0149
PMID:32996843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7698846/
Abstract

Peripheral follicular helper T (pTfh) cells represent specialized CD4 T cells that help B cells to secrete antibodies. Dengue infection appears to cause immune activation in a wide array of immune cells. Herein, we investigated the signatures of immune activation of circulating Tfh cells and mucosal-associated invariant T (MAIT) cells in adult subjects with confirmed acute clinical dengue virus (DENV) infection by multiparametric flow cytometry. The acute DENV infection induced a significant expansion of highly activated pTfh cells and circulating MAIT cells during acute febrile infection. We found a higher frequency of activated PD-1 Tfh cells and CD38 pTfh cells in clinical DENV infection. We also found similar activated and expanding phenotypes of MAIT cells in the patients tested. The total counts of activated pTfh cells and circulating MAIT cells were higher in dengue patients relative to healthy controls. We concluded that pTfh cells and circulating MAIT cells represent activated phenotypes in acute DENV infection.

摘要

外周滤泡辅助 T（pTfh）细胞代表了一类专门的 CD4 T 细胞，它们有助于 B 细胞分泌抗体。登革热感染似乎会引起广泛的免疫细胞的免疫激活。在此，我们通过多参数流式细胞术研究了成人确诊急性临床登革热病毒（DENV）感染患者循环 Tfh 细胞和黏膜相关不变 T（MAIT）细胞的免疫激活特征。急性 DENV 感染在急性发热感染期间诱导高度活化的 pTfh 细胞和循环 MAIT 细胞的显著扩增。我们发现在临床 DENV 感染中，活化的 PD-1 Tfh 细胞和 CD38 pTfh 细胞的频率更高。我们还发现，在检测的患者中，MAIT 细胞也具有相似的活化和扩增表型。与健康对照组相比，登革热患者的活化 pTfh 细胞和循环 MAIT 细胞总数更高。我们得出结论，pTfh 细胞和循环 MAIT 细胞在急性 DENV 感染中代表活化表型。