涂片显微镜检查和 Xpert assay 用于结核病诊断的成本分析：平均周转时间。
Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosis: average turnaround time.
机构信息
Universidade Federal de Minas Gerais, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais, Grupo de Pesquisa em Micobacterioses, Faculdade de Medicina, Belo Horizonte, MG, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Sep 25;53:e20200314. doi: 10.1590/0037-8682-0314-2020. eCollection 2020.
INTRODUCTION
Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy and Xpert assay at a university hospital.
METHODS
The turnaround time and cost of the laboratory diagnosis of tuberculosis were calculated based on the mean cost and activity based costing (ABC).
RESULTS
The average turnaround time for smear microscopy was 16.6 hours while that for Xpert was 24.1 hours. The Xpert had a mean cost of USD 17.37 with an ABC of USD 10.86, while smear microscopy had a mean cost of USD 13.31 with an ABC of USD 6.01. The sensitivity of smear microscopy was 42.9% and its specificity was 99.1%, while the Xpert assay had a sensitivity of 100% and a specificity of 96.7%.
CONCLUSIONS
The Xpert assay has high accuracy; however, the turnaround time and cost of smear microscopy were lower than those of Xpert.
简介
快速准确地检测结核病对于改善患者诊断和减少结核病传播至关重要。分子检测可显著增加实验室成本；因此，在实施新技术之前，应评估其平均时间和经济影响。本研究旨在评估大学医院中痰涂片显微镜检查和 Xpert 检测的成本和平均周转时间。
方法
根据平均成本和作业成本法（ABC）计算结核病实验室诊断的周转时间和成本。
结果
痰涂片显微镜检查的平均周转时间为 16.6 小时，而 Xpert 的平均周转时间为 24.1 小时。Xpert 的平均成本为 17.37 美元，ABC 为 10.86 美元，而痰涂片显微镜检查的平均成本为 13.31 美元，ABC 为 6.01 美元。痰涂片显微镜检查的灵敏度为 42.9%，特异性为 99.1%，而 Xpert 检测的灵敏度为 100%，特异性为 96.7%。
结论
Xpert 检测具有很高的准确性；然而，痰涂片显微镜检查的周转时间和成本均低于 Xpert。
Zotero 插件