Nadzirah Sh, Gopinath Subash C B, Parmin N A, Hamzah Azrul Azlan, Mohamed Mohd Ambri, Chang Edward Yi, Dee Chang Fu
Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia.
Crit Rev Anal Chem. 2022;52(3):637-648. doi: 10.1080/10408347.2020.1816447. Epub 2020 Sep 30.
Biosensors operating based on electrical methods are being accelerated toward rapid and efficient detection that improve the performance of the device. Continuous study in nano- and material-sciences has led to the inflection with properties of nanomaterials that fit the trend parallel to the biosensor evolution. Advancements in technology that focuses on nano-hybrid are being used to develop biosensors with better detection strategies. In this sense, titanium dioxide (TiO) nanomaterials have attracted extensive interest in the construction of electrical biosensors. The formation of TiO nano-hybrid as an electrical transducing material has revealed good results with high performance. The modification of the sensing portion with a combination (nano-hybrid form) of nanomaterials has produced excellent sensors in terms of stability, reproducibility, and enhanced sensitivity. This review highlights recent research advancements with functional TiO nano-hybrid materials, and their victorious story in the construction of electrical biosensors are discussed. Future research directions with commercialization of these devices and their extensive utilizations are also discussed.
基于电学方法运行的生物传感器正朝着快速高效检测的方向加速发展,以提高设备性能。纳米科学和材料科学的持续研究已导致纳米材料特性的转变,这些特性与生物传感器的发展趋势相契合。专注于纳米杂化的技术进步正被用于开发具有更好检测策略的生物传感器。从这个意义上说,二氧化钛(TiO)纳米材料在电化学生物传感器的构建中引起了广泛关注。作为电传感材料的TiO纳米杂化材料的形成已显示出高性能的良好结果。用纳米材料组合(纳米杂化形式)对传感部分进行修饰,在稳定性、重现性和增强灵敏度方面产生了优异的传感器。本综述重点介绍了功能性TiO纳米杂化材料的最新研究进展,并讨论了它们在电化学生物传感器构建中的成功案例。还讨论了这些设备商业化及其广泛应用的未来研究方向。