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肝细胞癌肿瘤微环境中CD8 T细胞的免疫代谢靶点

Immunometabolic Targets in CD8 T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma.

作者信息

Lin Yanze, Ruze Rexiati, Zhang Ruiqing, Tuergan Talaiti, Wang Maolin, Tulahong Alimu, Zhu Dalong, Yuan Zhongdian, Jiang Tiemin, Aji Tuerganaili, Shao Yingmei

机构信息

Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.

Clinical Research Center for Echinococcosis and Hepatobiliary Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.

出版信息

Liver Cancer. 2024 Nov 21;14(4):474-496. doi: 10.1159/000542578. eCollection 2025 Aug.

DOI:10.1159/000542578
PMID:40831886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12360748/
Abstract

BACKGROUND: CD8 T cells are critical for the oncogenesis and progression of the hepatocellular carcinoma (HCC) tumor microenvironment, receiving antigen signals from antigen-presenting cells and directly contributing to antitumor responses. SUMMARY: CD8 T cells mediate immunogenic cell death, facilitate immune signal transmission, and play a significant role in various treatments, including surgery, transarterial chemoembolization, and immunotherapy. Extensive research on the role of CD8 T cells within the HCC microenvironment has shown considerable progress. Immunometabolic targets on CD8 T cells have demonstrated potential in combination with immunotherapies for HCC; however, they have not yet reached the clinical trial stage. KEY MESSAGES: This review provides a comprehensive overview of recent research on immune and immunometabolic targets of CD8 T cells within the HCC microenvironment. By highlighting advances and potential mechanisms, this review aims to support the development of effective clinical strategies in this field.

摘要

背景：CD8 T细胞对于肝细胞癌（HCC）肿瘤微环境的肿瘤发生和进展至关重要，它从抗原呈递细胞接收抗原信号并直接促进抗肿瘤反应。 总结：CD8 T细胞介导免疫原性细胞死亡，促进免疫信号传递，并在包括手术、经动脉化疗栓塞和免疫治疗在内的各种治疗中发挥重要作用。对HCC微环境中CD8 T细胞作用的广泛研究已取得显著进展。CD8 T细胞上的免疫代谢靶点已显示出与HCC免疫疗法联合使用的潜力；然而，它们尚未进入临床试验阶段。 关键信息：本综述全面概述了HCC微环境中CD8 T细胞免疫和免疫代谢靶点的最新研究。通过强调进展和潜在机制，本综述旨在支持该领域有效临床策略的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/80a0008087cd/lic-2025-0014-0004-542578_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/7a356d201319/lic-2025-0014-0004-542578_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/deae38668e47/lic-2025-0014-0004-542578_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/468cb6d23378/lic-2025-0014-0004-542578_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/d70bb42eebc4/lic-2025-0014-0004-542578_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/80a0008087cd/lic-2025-0014-0004-542578_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/7a356d201319/lic-2025-0014-0004-542578_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/deae38668e47/lic-2025-0014-0004-542578_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/468cb6d23378/lic-2025-0014-0004-542578_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/d70bb42eebc4/lic-2025-0014-0004-542578_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e2/12360748/80a0008087cd/lic-2025-0014-0004-542578_F05.jpg

相似文献

[1]
Immunometabolic Targets in CD8 T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma.

Liver Cancer. 2024-11-21

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HLA-DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T-Cell Exhaustion in HBV-Associated Hepatocellular Carcinoma.

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本文引用的文献

[1]
The Impact of TP53-Induced Glycolysis and Apoptosis Regulator on Prognosis in Hepatocellular Carcinoma: Association with Tumor Microenvironment and Ferroptosis.

Liver Cancer. 2024-8-12

[2]
High expression of circulating exosomal PD-L1 contributes to immune escape of hepatocellular carcinoma and immune clearance of chronic hepatitis B.

Aging (Albany NY). 2024-7-17

[3]
IMbrave152/SKYSCRAPER-14: a Phase III study of atezolizumab, bevacizumab and tiragolumab in advanced hepatocellular carcinoma.

Future Oncol. 2024

[4]
Patient-Reported Outcomes From the Phase III HIMALAYA Study of Tremelimumab Plus Durvalumab in Unresectable Hepatocellular Carcinoma.

J Clin Oncol. 2024-8-10

[5]
Bevacizumab induces ferroptosis and enhances CD8 T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9.

Acta Pharmacol Sin. 2024-9

[6]
PGE inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.

Nature. 2024-5

[7]
Hepatitis B Virus and Hepatitis C Virus Affect Mitochondrial Function Through Different Metabolic Pathways, Explaining Virus-Specific Clinical Features of Chronic Hepatitis.

J Infect Dis. 2024-11-15

[8]
A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle.

J Exp Clin Cancer Res. 2024-3-8

[9]
Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8 T cells.

Cell Death Dis. 2024-2-15

[10]
Metabolic reprogramming in the tumor microenvironment of liver cancer.

J Hematol Oncol. 2024-1-31

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