加拿大青年结直肠癌的发病率持续上升。
The incidence of young-onset colorectal cancer in Canada continues to increase.
机构信息
Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Department of Oncology, University of Calgary, Calgary, AB, Canada; Forzani & MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada.
Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Forzani & MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
出版信息
Cancer Epidemiol. 2020 Dec;69:101828. doi: 10.1016/j.canep.2020.101828. Epub 2020 Sep 28.
BACKGROUND
Despite decreases in the overall incidence of colorectal cancer (CRC) in Canada, a concerning increase has been observed among younger adults in recent years. The aim of this study was to update age-specific incidence trends of CRC from 1971 to 2017 in Canada.
METHODS
Data was obtained from the National Cancer Incidence Reporting System and the Canadian Cancer Registry. Age-specific annual percent changes in the incidence of CRC was estimated using NCI's Joinpoint Regression Program.
RESULTS
The incidence of CRC among adults over age 50 has continued to decrease, while the incidence among adults under the age of 50 has continued to rise. The largest increases have occurred among 20-29 and 30-39 age groups for colon and rectal cancers, respectively.
CONCLUSION
The incidence of CRC among young adults, particularly those under 40, continues to increase among men and women in Canada. Studies examining potential risk factors for young-onset CRC are required.
背景
尽管加拿大结直肠癌（CRC）的总体发病率有所下降，但近年来，年轻人群中的发病率却令人担忧地有所上升。本研究旨在更新 1971 年至 2017 年加拿大 CRC 的年龄特异性发病率趋势。
方法
数据来自国家癌症发病率报告系统和加拿大癌症登记处。使用 NCI 的 Joinpoint 回归程序估计 CRC 的年龄特异性年度百分比变化。
结果
50 岁以上成年人的 CRC 发病率持续下降，而 50 岁以下成年人的 CRC 发病率持续上升。结肠癌和直肠癌在 20-29 岁和 30-39 岁年龄组中的发病率增长最大。
结论
在加拿大，年轻成年人（尤其是 40 岁以下的成年人）CRC 的发病率在男性和女性中仍在持续上升。需要研究年轻人 CRC 的潜在危险因素。
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