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从 SARS-CoV-2 阳性女性的卵母细胞中检测不到病毒 RNA。

Undetectable viral RNA in oocytes from SARS-CoV-2 positive women.

机构信息

Clinica EUGIN, Carrer de Balmes 236, Barcelona 08006, Spain.

出版信息

Hum Reprod. 2021 Jan 25;36(2):390-394. doi: 10.1093/humrep/deaa284.

DOI:10.1093/humrep/deaa284
PMID:32998162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7543480/
Abstract

A central concern for the safe provision of ART during the current coronavirus disease 2019 (COVID-19) pandemic is the possibility of vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through gametes and preimplantation embryos. Unfortunately, data on SARS-CoV-2 viral presence in oocytes of infected individuals are not available to date. We describe the case of two women who underwent controlled ovarian stimulation and tested positive to SARS-CoV-2 infection by PCR on the day of oocyte collection. The viral RNA for gene N was undetectable in all the oocytes analyzed from the two women.

摘要

目前 2019 冠状病毒病(COVID-19)大流行期间,安全提供辅助生殖技术(ART)的一个核心关注点是,严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染是否可能通过配子和着床前胚胎垂直传播。遗憾的是,目前尚无关于感染个体卵母细胞中 SARS-CoV-2 病毒存在情况的数据。我们报告了两例在取卵日经 PCR 检测 SARS-CoV-2 感染呈阳性的妇女,她们接受了控制性卵巢刺激。从这两名妇女中分析的所有卵母细胞中均未检测到基因 N 的病毒 RNA。

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