间日疟原虫、卵形疟原虫或三日疟原虫感染的成年患者治疗期间及治疗后的氯喹和脱乙基氯喹全血浓度。
Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, P. ovale or P. malariae.
作者信息
Rombo L, Björkman A, Sego E, Ericsson O
出版信息
Trans R Soc Trop Med Hyg. 1986;80(5):763-6. doi: 10.1016/0035-9203(86)90380-9.
Whole blood concentrations of chloroquine and desethychloroquine were determined during and after chloroquine treatment of 15 adult patients infected with P. vivax, P. ovale or P. malariae. The median of chloroquine concentrations remained practically unchanged in samples drawn three hours after initiation of treatment and in samples drawn immediately before the next dose of chloroquine. Concentrations of chloroquine remained above 1.0 mumol/litre for at least four days. The calculated sum of chloroquine and desethylchloroquine concentrations was above 1.0 mumol/litre for at least seven days. These concentrations are regarded as sufficient for treatment of P. vivax, P. ovale and P. malariae infections.
对15例感染间日疟原虫、卵形疟原虫或三日疟原虫的成年患者进行氯喹治疗期间及之后，测定了全血中氯喹和去乙基氯喹的浓度。治疗开始三小时后采集的样本以及在下一剂氯喹给药前立即采集的样本中，氯喹浓度中位数基本保持不变。氯喹浓度至少四天保持在1.0微摩尔/升以上。氯喹和去乙基氯喹浓度的计算总和至少七天保持在1.0微摩尔/升以上。这些浓度被认为足以治疗间日疟原虫、卵形疟原虫和三日疟原虫感染。
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