Baird J K, Leksana B, Masbar S, Sutanihardja M A, Fryauff D J, Subianto B
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
Am J Trop Med Hyg. 1997 Jun;56(6):618-20. doi: 10.4269/ajtmh.1997.56.618.
Whole blood concentrations of self-administered chloroquine (CQ) and its metabolite desethylchloroquine (DCQ) were measured in 168 patients with microscopically confirmed infection by Plasmodium vivax in northeastern Irian Jaya, Indonesia. The study consisted of both survey and passive case detection in four separate villages between 1992 and 1994. The subjects were Javanese people 4-51 years old who had lived in the Arso region for up to two years. The sum of CQ and DCQ ranged from 0 to 8,342 ng/ml of whole blood, and 122 subjects (73%) had > or = 100 ng/ml of CQ plus DCQ, the estimated minimally effective concentration (MEC) in whole blood against chloroquine-sensitive P. vivax. Among 56 subjects reporting to a clinic with symptoms of malaria, 53 (95%) had ordinarily effective levels of chloroquine in blood. Among 109 largely asymptomatic malaria patients found by survey case detection, 69 (63%) had chloroquine blood levels greater than the MEC. Virtually all clinical and most subclinical vivax malaria in this region occurs despite ordinarily effective levels of chloroquine in blood.
在印度尼西亚伊里安查亚省东北部，对168例经显微镜确诊为间日疟原虫感染的患者进行了自服氯喹（CQ）及其代谢产物去乙基氯喹（DCQ）的全血浓度测定。该研究在1992年至1994年期间，于四个不同的村庄开展了调查和被动病例检测。研究对象为4至51岁、在阿尔索地区居住长达两年的爪哇人。全血中CQ与DCQ浓度之和为0至8342纳克/毫升，122名受试者（73%）的CQ加DCQ浓度≥100纳克/毫升，这是全血中针对氯喹敏感间日疟原虫的估计最低有效浓度（MEC）。在56名因疟疾症状到诊所就诊的受试者中，53人（95%）血液中的氯喹水平通常有效。在通过调查病例检测发现的109名基本无症状的疟疾患者中，69人（63%）的氯喹血药浓度高于MEC。尽管该地区血液中氯喹水平通常有效，但几乎所有临床和大多数亚临床间日疟仍有发生。
