Marasca Claudio, Ruggiero Angelo, Fabbrocini Gabriella, Megna Matteo
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Case Rep Dermatol. 2020 Aug 18;12(2):155-158. doi: 10.1159/000509176. eCollection 2020 May-Aug.
Eosinophilic pustular folliculitis (EPF) (Ofuji disease) is a chronic, noninfectious pruritic cutaneous disorder of unknown etiology. No official guidelines are available for its treatment. Herein we present the case of a 59-year-old Caucasian man admitted to our outpatient clinic due to a generalized itchy skin rash characterized by papulo-pustules involving the face, trunk, and limbs. Histological examination supported the clinical diagnosis of EPF (Ofuji disease). The combination of low-dose oral indomethacin and topical tacrolimus ointment once a day led to a complete resolution of the lesions as well as associated symptoms in 8 weeks.
嗜酸性脓疱性毛囊炎（EPF）（Ofuji病）是一种病因不明的慢性、非感染性瘙痒性皮肤病。目前尚无针对其治疗的官方指南。在此，我们报告一例59岁的白种男性患者，因全身性瘙痒性皮疹就诊于我们的门诊，皮疹表现为面部、躯干和四肢的丘疹脓疱。组织学检查支持EPF（Ofuji病）的临床诊断。低剂量口服吲哚美辛与外用他克莫司软膏每日一次联合使用，8周后皮损及相关症状完全消退。
