低剂量吲哚美辛与外用他克莫司联合成功治疗奥富士病1例
A Case of Ofuji Disease Successfully Treated with the Combination of Low-Dose Indomethacin and Topical Tacrolimus.
作者信息
Marasca Claudio, Ruggiero Angelo, Fabbrocini Gabriella, Megna Matteo
机构信息
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
出版信息
Case Rep Dermatol. 2020 Aug 18;12(2):155-158. doi: 10.1159/000509176. eCollection 2020 May-Aug.
Eosinophilic pustular folliculitis (EPF) (Ofuji disease) is a chronic, noninfectious pruritic cutaneous disorder of unknown etiology. No official guidelines are available for its treatment. Herein we present the case of a 59-year-old Caucasian man admitted to our outpatient clinic due to a generalized itchy skin rash characterized by papulo-pustules involving the face, trunk, and limbs. Histological examination supported the clinical diagnosis of EPF (Ofuji disease). The combination of low-dose oral indomethacin and topical tacrolimus ointment once a day led to a complete resolution of the lesions as well as associated symptoms in 8 weeks.
嗜酸性脓疱性毛囊炎（EPF）（Ofuji病）是一种病因不明的慢性、非感染性瘙痒性皮肤病。目前尚无针对其治疗的官方指南。在此，我们报告一例59岁的白种男性患者，因全身性瘙痒性皮疹就诊于我们的门诊，皮疹表现为面部、躯干和四肢的丘疹脓疱。组织学检查支持EPF（Ofuji病）的临床诊断。低剂量口服吲哚美辛与外用他克莫司软膏每日一次联合使用，8周后皮损及相关症状完全消退。
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