Jukes Catherine, Bjerre Anne, Coupe Jacqueline, Gibson Josephine
Blackpool Teaching Hospital NHS Foundation Trust, GB.
The University of Sheffield, GB.
Br Ir Orthopt J. 2019 Jul 4;15(1):115-124. doi: 10.22599/bioj.132.
BACKGROUND/AIMS: Computer games have been used to stimulate vision in amblyopia with varying degrees of success. The aim of this pilot study was to evaluate the feasibility of conducting a randomised controlled trial to test the effectiveness of computer game play compared to close work during occlusion treatment in children.
Children aged 2-7 years with amblyopia and no prior amblyopia treatment were invited to participate. Participants were randomised to a computer game group or close work group and asked to complete two hours occlusion per day, incorporating one hour of their allocated activity. LogMAR visual acuity (VA) was assessed before treatment commenced and after 7(±1) weeks. The same examiner, who was unaware of the allocated treatment, assessed the participant using the same VA test.
Eighteen participants (mean age of 4.2 ± 1.3 years) completed the study. After seven weeks the mean VA of the amblyopic eye in the computer game group improved by 0.147 ± 0.182 logMAR, and in the close work group improved by 0.181 ± 0.124 logMAR. The difference in VA improvement between the computer game and the close work groups was not statistically significant (F = 3.71; p = 0.06).
No significant difference was found in visual outcomes between the two groups, but a larger sample size would be needed to draw conclusions regarding the amblyopic population. Evaluation of the study design suggests it would be feasible to conduct a randomised controlled trial comparing computer games and close work during occlusion to determine if a significant difference in visual outcome exists.
背景/目的：电脑游戏已被用于刺激弱视患者的视力，取得了不同程度的成功。这项初步研究的目的是评估进行一项随机对照试验的可行性，以测试在儿童遮盖治疗期间，与近距离工作相比，玩电脑游戏的效果。
邀请2至7岁患有弱视且此前未接受过弱视治疗的儿童参与。参与者被随机分为电脑游戏组或近距离工作组，并被要求每天进行两小时的遮盖，其中包括一小时分配给他们的活动。在治疗开始前和7（±1）周后评估LogMAR视力（VA）。由同一位不知道分配治疗情况的检查者使用相同的视力测试对参与者进行评估。
18名参与者（平均年龄4.2±1.3岁）完成了研究。七周后，电脑游戏组弱视眼的平均视力提高了0.147±0.182 LogMAR，近距离工作组提高了0.181±0.124 LogMAR。电脑游戏组和近距离工作组之间视力改善的差异无统计学意义（F = 3.71；p = 0.06）。
两组之间在视觉结果上未发现显著差异，但需要更大的样本量才能就弱视人群得出结论。对研究设计的评估表明，进行一项随机对照试验比较遮盖期间的电脑游戏和近距离工作，以确定视觉结果是否存在显著差异是可行的。
