Alison R H, Lewis D J, Montgomery C A
Vet Pathol. 1987 May;24(3):226-30. doi: 10.1177/030098588702400305.
Choriocarcinoma is one of the rarest ovarian tumors in any animal species. This paper describes the gross and microscopic appearance of seven such neoplasms in B6C3F1 mice. Mean age at death was 47 weeks. Tumors were described at necropsy as dark or hemorrhagic cystic lesions. On microscopic examination tumors were composed of hematocysts, intercellular hemorrhage, and cytotrophoblasts, syncytiotrophoblasts, and/or trophoblastic giant cells. Cytotrophoblasts, syncytiotrophoblasts, and occasional giant cells were present in three cases while the other four tumors contained only trophoblastic giant cells.
绒毛膜癌是所有动物物种中最罕见的卵巢肿瘤之一。本文描述了B6C3F1小鼠中7例此类肿瘤的大体和显微镜下表现。死亡时的平均年龄为47周。尸检时肿瘤被描述为深色或出血性囊性病变。显微镜检查显示，肿瘤由血囊肿、细胞间出血以及细胞滋养层细胞、合体滋养层细胞和/或滋养层巨细胞组成。3例肿瘤中存在细胞滋养层细胞、合体滋养层细胞和偶尔的巨细胞，而其他4例肿瘤仅含有滋养层巨细胞。
