MER2：一种由单克隆抗体定义的红细胞多态性。

MER2: a red cell polymorphism defined by monoclonal antibodies.

作者信息

Daniels G L, Tippett P, Palmer D K, Miller Y E, Geyer D, Jones C

出版信息

Vox Sang. 1987;52(1-2):107-10. doi: 10.1111/j.1423-0410.1987.tb03002.x.

DOI:10.1111/j.1423-0410.1987.tb03002.x

Abstract

Two murine monoclonal antibodies, 1D12 and 2F7, apparently of the same specificity, define a new red cell polymorphism, MER2. 92% of English blood donors are MER2+ giving the gene frequencies MER2+ 0.7159; MER2- 0.2841. Family studies showed that MER2+ is inherited as a Mendelian dominant character and that MER2 is not controlled by any of the main blood group loci. The MER2 antigen is also present on some leukaemia fibroblasts and human cell lines. Using somatic cell hybrids, MER2 appears to be coded for by a gene on chromosome 11 at 11p15.

摘要

两种小鼠单克隆抗体1D12和2F7，显然具有相同的特异性，它们定义了一种新的红细胞多态性，即MER2。92%的英国献血者为MER2阳性，基因频率分别为：MER2阳性0.7159；MER2阴性0.2841。家系研究表明，MER2阳性作为孟德尔显性性状遗传，且MER2不受任何主要血型位点控制。MER2抗原也存在于一些白血病成纤维细胞和人类细胞系中。利用体细胞杂种，MER2似乎由位于11号染色体11p15处的一个基因编码。