α-8整合素链（itga8）在肾脏肾小球稳态中的作用。
A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney.
作者信息
Marek Ines, Hilgers Karl Friedrich, Rascher Wolfgang, Woelfle Joachim, Hartner Andrea
机构信息
Department of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Loschgestrasse 15, 91054, Erlangen, Germany.
Department of Nephrology and Hypertension, University Hospital of Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
出版信息
Mol Cell Pediatr. 2020 Oct 1;7(1):13. doi: 10.1186/s40348-020-00105-5.
Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8 integrin chain seems to be an important player to maintain glomerular homeostasis by conferring mechanical stability and functional support for the renal capillary tuft.
肾小球肾炎会导致肾小球细胞调节异常，并最终可能导致慢性改变以及随后的肾功能丧失。因此，了解有助于维持肾小球完整性的机制是治疗干预的关键前提。α-8整合素链似乎是通过赋予肾毛细血管袢机械稳定性和功能支持来维持肾小球稳态的重要因素。
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