State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.
Macromol Rapid Commun. 2020 Dec;41(24):e2000468. doi: 10.1002/marc.202000468. Epub 2020 Sep 30.
This work reports the ionic composition of a PEGylated and chemically crosslinked polyethyleneimine with a gadolinium-coordinated polyoxomolybdate cluster, K [Gd(P Mo O ) ], via electrostatic interaction. The prepared composites form nanoobjects with an average size of ≈27 nm at dried state and maintain structural stability in aqueous solution. While the biocompatibility on HeLa cells is demonstrated, the polymer-shielded multifunctional nanoplatform shows both the combined magnetic resonance imaging and redox-triggered photothermal conversion effect. As a contrast agent, the T -weighed relaxivity reaches up to 22.77 mm s . The photothermal conversion of the prepared composites can be aroused by yielding a broad near infrared (NIR) adsorption through on-site reduction of the glutathione that is enriched in the tumor environment. The high efficiency ≈61.0% under the irradiation of 808 nm NIR laser illustrates a distinct treatment capability according to cell counting Kit-8 assay while the obvious inhibition for the growth of tumor cells is observed.
这项工作报道了一种通过静电相互作用将聚乙二醇化和化学交联的聚乙烯亚胺与钆配位的多钼酸盐簇 K[Gd(P Mo O )] 离子化。在干燥状态下，制备的复合材料形成平均尺寸约为 27nm 的纳米物体，并在水溶液中保持结构稳定性。在证明了其生物相容性的同时，聚合物屏蔽的多功能纳米平台显示出了磁共振成像和氧化还原触发的光热转换效应的双重作用。作为造影剂，T 加权弛豫率高达 22.77mm 1 s -1 。通过在富含肿瘤环境中的谷胱甘肽的原位还原产生宽近红外（NIR）吸收，可引发制备的复合材料的光热转换。在 808nmNIR 激光照射下，效率高达 61.0%，根据细胞计数试剂盒-8 测定，表明具有明显的治疗能力，同时观察到肿瘤细胞生长明显受到抑制。
