Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States.
Org Lett. 2020 Oct 16;22(20):7971-7975. doi: 10.1021/acs.orglett.0c02815. Epub 2020 Oct 1.
Herein, we describe an organic photoredox system for direct arene C-H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics. We also demonstrate the feasibility of C-H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.
在此,我们描述了一种使用过氧化物氧化剂和 LED 作为光源的有机光氧化还原体系,用于直接芳环 C-H 放射性氟化。结合优化的光催化剂和微管反应器,该体系适用于一系列富电子芳烃和杂芳烃。我们还证明了无需共沸干燥步骤进行 C-H 放射性氟化的可行性,这大大简化了标记过程的工作流程。