Hakumäki M O
Acta Physiol Scand. 1987 Jun;130(2):177-85. doi: 10.1111/j.1748-1716.1987.tb08126.x.
The discovery of the Bainbridge reflex 70 years ago, of a tachycardic response to a rise in central venous pressure, stimulated a lot of interest in this and other cardiovascular reflexes. The mechanoreceptors that elicit the reflex are located at the junction of the right atrium and caval veins or at the junctions of the pulmonary veins and the left atrium. The Bainbridge reflex is controversial, however, because its existence cannot always be demonstrated. Intravenous infusions, which usually elicit a reflex tachycardia, sometimes cause a bradycardic response. This paper reviews the history of the studies associated with the reflex. Results are reported, which demonstrate that the chronotropic response to i.v. infusions depends upon the resulting change in aortic diameter; bradycardia is evoked by infusions leading to a rise in aortic baroreceptor activity through increases in aortic diameter, volume or pressure; tachycardia follows whenever the infusion fails to trigger the baroreflex. The importance of the Bainbridge reflex as a counterbalance to the baroreceptor reflex is discussed.
70年前发现的 Bainbridge 反射，即中心静脉压升高时的心动过速反应，引发了人们对该反射及其他心血管反射的浓厚兴趣。引发该反射的机械感受器位于右心房与腔静脉的交界处，或肺静脉与左心房的交界处。然而，Bainbridge 反射存在争议，因为其存在并非总能得到证实。静脉输注通常会引发反射性心动过速，但有时也会导致心动过缓反应。本文回顾了与该反射相关的研究历史。报告了相关结果，结果表明，对静脉输注的变时反应取决于主动脉直径的变化；导致主动脉直径、容积或压力增加从而使主动脉压力感受器活动增强的输注会引发心动过缓；只要输注未能触发压力感受器反射，就会出现心动过速。文中还讨论了 Bainbridge 反射作为压力感受器反射平衡机制的重要性。
