Institute for integrated Cell-Material Sciences (WPI-iCeMS), KUIAS, Kyoto University, Japan.
FEBS Lett. 2020 Dec;594(23):3876-3881. doi: 10.1002/1873-3468.13945. Epub 2020 Oct 13.
ATP-binding cassette (ABC) proteins play diverse roles in all living organisms, making them an attractive model for evolution. Early evolution of ancestral unicellular organisms entailed the acquisition of at least three types of ABC proteins: type 1 ABC proteins to import nutrients, and type 2 and 3 ABC proteins to generate the outer cell membrane by flopping and loading lipids onto acceptors, respectively. To export various toxic lipophilic compounds, cells evolutionarily acquired a fourth type of ABC protein. This suggests that ABC proteins may have played an important role in evolution, especially when life became terrestrial, protecting plants and animals from water loss and pathogen infection. ABC proteins are also assumed to have accelerated the evolution of vertebrates by allowing cholesterol to function for intramembrane signaling. In this review, we discuss the roles of ABC proteins in the evolution of bacteria, plants, and animals.
ATP 结合盒（ABC）蛋白在所有生物中发挥着多样化的作用，使它们成为进化研究的理想模型。原始单细胞生物的早期进化至少获得了三种类型的 ABC 蛋白：第一类 ABC 蛋白用于吸收营养物质，第二类和第三类 ABC 蛋白通过翻转和将脂质加载到受体上来分别产生外细胞膜。为了排出各种有毒脂溶性化合物，细胞进化获得了第四种类型的 ABC 蛋白。这表明 ABC 蛋白可能在进化中发挥了重要作用，尤其是当生命变得陆地化时，它们可以保护植物和动物免受水分流失和病原体感染。ABC 蛋白还通过允许胆固醇发挥膜内信号作用，从而加速了脊椎动物的进化。在这篇综述中，我们讨论了 ABC 蛋白在细菌、植物和动物进化中的作用。
