Wu Danxia, Saleem Muhammad, He Tengbing, He Guandi
College of Agricultural, Guizhou University, Guiyang 550025, China.
Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA.
Membranes (Basel). 2021 Dec 15;11(12):984. doi: 10.3390/membranes11120984.
Heavy metal stress (HMS) is one of the most destructive abiotic stresses which seriously affects the growth and development of plants. Recent studies have shown significant progress in understanding the molecular mechanisms underlying plant tolerance to HMS. In general, three core signals are involved in plants' responses to HMS; these are mitogen-activated protein kinase (MAPK), calcium, and hormonal (abscisic acid) signals. In addition to these signal components, other regulatory factors, such as microRNAs and membrane proteins, also play an important role in regulating HMS responses in plants. Membrane proteins interact with the highly complex and heterogeneous lipids in the plant cell environment. The function of membrane proteins is affected by the interactions between lipids and lipid-membrane proteins. Our review findings also indicate the possibility of membrane protein-lipid-metal ion interactions in regulating metal homeostasis in plant cells. In this review, we investigated the role of membrane proteins with specific substrate recognition in regulating cell metal homeostasis. The understanding of the possible interaction networks and upstream and downstream pathways is developed. In addition, possible interactions between membrane proteins, metal ions, and lipids are discussed to provide new ideas for studying metal homeostasis in plant cells.
重金属胁迫（HMS）是最具破坏性的非生物胁迫之一，严重影响植物的生长发育。最近的研究表明，在理解植物对HMS耐受性的分子机制方面取得了重大进展。一般来说，植物对HMS的反应涉及三个核心信号；这些信号是丝裂原活化蛋白激酶（MAPK）、钙和激素（脱落酸）信号。除了这些信号成分外，其他调节因子，如微小RNA和膜蛋白，在调节植物对HMS的反应中也起着重要作用。膜蛋白与植物细胞环境中高度复杂且异质的脂质相互作用。膜蛋白的功能受脂质与脂质-膜蛋白之间相互作用的影响。我们的综述结果还表明，膜蛋白-脂质-金属离子相互作用在调节植物细胞金属稳态方面具有可能性。在本综述中，我们研究了具有特定底物识别功能的膜蛋白在调节细胞金属稳态中的作用。对可能的相互作用网络以及上游和下游途径的理解得到了发展。此外，还讨论了膜蛋白、金属离子和脂质之间可能的相互作用，为研究植物细胞中的金属稳态提供新思路。
