Nucleus Applied to Toxicology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, Brazil.
Nucleus Applied to Toxicology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria, Brazil.
Clin Chim Acta. 2020 Dec;511:47-49. doi: 10.1016/j.cca.2020.09.034. Epub 2020 Sep 28.
Methyl ethyl ketone peroxide (MEKP) is a highly toxic product which promotes tissue damage by uncontrolled free radical production.
A man accidentally ingested 110 ml of MEKP (37%) at his workplace after mistaking it with a bottle of water. A loading dose of N-acetylcysteine (NAC) and subsequent maintenance doses were applied at the hospital for three consecutive days. Biochemical and hematological parameters showed significant alterations. Tracheal intubation, gastric lavage and hemodialysis were not performed. Methyl ethyl ketone (MEK) and MEKP were detected in EDTA-blood samples by GC-FID and LC-QTOF/MS respectively. An endoscopy exam identified tissue damage. The patient was admitted to the hospital for 10 days. No sequelae were reported after the MEKP poisoning. Oral administration of NAC was successful as an antidote without another approach.
Although NAC treatment was successful, supervision after the hospitalization period was required according to the prognosis. Workplace conditions promoted anosmia, explaining the accident. MEKP and MEK were successfully detected in blood samples even with less-than-ideal storage conditions. Knowledge of MEKP dangerousness and good work practices can prevent accidental MEKP poisoning.
甲乙酮过氧化物（MEKP）是一种毒性很高的产品，会通过产生不受控制的自由基而促进组织损伤。
一名男子在工作时误将 110 毫升 MEKP（37%）当作水喝下。在医院连续三天给予了 N-乙酰半胱氨酸（NAC）负荷剂量和随后的维持剂量。生化和血液参数显示出明显的改变。未进行气管插管、洗胃和血液透析。通过 GC-FID 和 LC-QTOF/MS 分别在 EDTA 血液样本中检测到甲乙酮（MEK）和甲乙酮过氧化物（MEKP）。内窥镜检查发现组织损伤。该患者住院 10 天。MEKP 中毒后无后遗症报告。口服 NAC 作为解毒剂成功，未采用其他方法。
尽管 NAC 治疗成功，但根据预后仍需要在住院期间后进行监测。工作场所条件导致嗅觉丧失，这解释了事故的发生。即使在不太理想的储存条件下，MEKP 和 MEK 也能成功地在血液样本中检测到。了解 MEKP 的危险性和良好的工作实践可以预防意外的 MEKP 中毒。
