Department of Poisoning and Occupational Diseases, 12589Shandong University, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
School of Public Health, Cheeloo College of Medicine, 12589Shandong University, Shandong University, Jinan, Shandong, China.
J Int Med Res. 2022 Jan;50(1):3000605211067694. doi: 10.1177/03000605211067694.
We report two suicidal cases of acute methyl ethyl ketone peroxide (MEKP) poisoning. A woman in her late 60s suffered from oral mucosal erosion, functional impairment of the heart, liver and other organs, pulmonary inflammation, elevated inflammatory markers, pleural effusion, hypoproteinemia and metabolic acidosis after oral administration of approximately 50 mL of MEKP. After admission, the patient was administered hemoperfusion four times, 8 mg of betamethasone for 6 days and symptomatic support. Hemoperfusion had an obvious effect on the treatment of oral MEKP poisoning. After discharge, the patient developed progressive dysphagia and secondary esophageal stenosis. Supplementary feeding was administered with a gastrostomy tube after the patient was completely unable to eat. A man in his mid-40s developed oropharyngeal mucosal erosion, bronchitis and esophageal wall thickening after oral administration of 40 ml MEKP. After receiving total gastrointestinal dispersal, 80 mg of methylprednisolone was administered for 7 days, and symptomatic supportive treatment was provided. Slight dysphagia was observed after discharge, and there was no major effect on the quality of life. Patients with acute oral MEKP poisoning should be followed up regularly to observe its long-term effects on digestive tract corrosion and stenosis.
我们报告了两例急性甲乙酮过氧化物（MEKP）中毒的自杀病例。一名 60 多岁的女性口服约 50 毫升 MEKP 后，出现口腔黏膜糜烂、心脏、肝脏等多器官功能障碍、肺部炎症、炎症标志物升高、胸腔积液、低蛋白血症和代谢性酸中毒。入院后，患者接受了 4 次血液灌流、6 天 8 毫克倍他米松和对症支持治疗。血液灌流对治疗口服 MEKP 中毒有明显效果。出院后，患者出现进行性吞咽困难和继发性食管狭窄。患者完全不能进食后，通过胃造口管进行补充喂养。一名 40 多岁的男性口服 40 毫升 MEKP 后出现口咽黏膜糜烂、支气管炎和食管壁增厚。接受全胃肠分散后，给予 80 毫克甲基强的松龙 7 天，并给予对症支持治疗。出院后出现轻微吞咽困难，对生活质量没有重大影响。急性口服 MEKP 中毒患者应定期随访，观察其对消化道腐蚀和狭窄的长期影响。
