School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, UK.
Department of Pharmaceutical Sciences, Pharmacy college, Princess Nourah bint Abdulrahman University, Saudi Arabia.
Adv Colloid Interface Sci. 2020 Nov;285:102273. doi: 10.1016/j.cis.2020.102273. Epub 2020 Sep 18.
The most common types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA) which are themain causes of disability and pain among older people. Current treatment of arthritis mainly consists of oral and intra-articular medications. Despite the efficacy of the intraarticular injections over the oral treatment, it is still limited by the rapid clearance of the injected drug. Therefore, a rational design of drug delivery systems (DDSs) able to delivery drugs in controlled manner and for required period of time to the arthritis joint is a key in developing safe and effective formulations for OA and RA. In this paper various colloidal systems like nanoparticles, liposomes, cationic carriers, hydrogels, and emulsion-based carriers were presented and discussed in light of their use and efficacy as delivery systems to transport therapeutics for arthritis treatment. Factors influencing the delivery efficacy such as size, charge, structure, drug uptake, retention and its release profile alongside with cytocompatibility and safety were addressed. Moreover, the advantages and disadvantages of the different colloidal systems were emphasised.
最常见的关节炎类型是骨关节炎（OA）和类风湿关节炎（RA），它们是老年人残疾和疼痛的主要原因。目前关节炎的治疗主要包括口服和关节内药物治疗。尽管关节内注射比口服治疗更有效，但它仍然受到注射药物快速清除的限制。因此，合理设计能够以受控方式和所需时间将药物递送到关节炎关节的药物递送系统（DDS）是开发 OA 和 RA 安全有效的制剂的关键。本文介绍了各种胶体系统，如纳米颗粒、脂质体、阳离子载体、水凝胶和乳剂载体，并根据它们作为递药系统的用途和功效进行了讨论，以输送治疗关节炎的药物。讨论了影响递药效果的因素，如大小、电荷、结构、药物摄取、保留及其释放特性，以及细胞相容性和安全性。此外，还强调了不同胶体系统的优缺点。
