Mendoza-Muñoz Néstor, Quintanar-Guerrero David, Allémann Eric
Laboratorio de Investigación y Posgrado en Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México. Av 1º de Mayo s/n, Col. Santa María las Torres, Cuautitlán Izcalli, Estado de México, México. C.P.54740.
Recent Pat Drug Deliv Formul. 2012 Dec;6(3):236-49. doi: 10.2174/187221112802652688.
The recent advances in nanotechnology and its application in medicine have merged into a new concept called nanomedicine. Colloidal drug delivery systems and specifically polymeric nanoparticles are one of the most promising novel drug carriers due to their capacity for passive or active targeting for therapeutic and diagnostic applications. The introduction of novel therapeutic nanoscaled agents requires simple, efficient and feasible industrial-scale production methods. Biodegradable polymeric nanoparticles are usually prepared from preformed polymers by five techniques: emulsification- solvent evaporation, solvent displacement, salting-out, emulsification-solvent diffusion and double emulsion solvent evaporation. This review discusses the use of the salting-out technique for the preparation of nanoparticles in the development of systems for drug delivery and other pharmaceutical applications. The relevant applications, formulations and release characteristics of novel colloidal drug delivery preparations from research literature and patents are summarized. This review is intended as a tool for the rational development of polymeric colloidal systems for pharmaceutical use.
纳米技术的最新进展及其在医学中的应用已融合成一个名为纳米医学的新概念。胶体药物递送系统，特别是聚合物纳米颗粒，因其能够被动或主动靶向用于治疗和诊断应用，是最有前景的新型药物载体之一。新型治疗性纳米级药物的引入需要简单、高效且可行的工业规模生产方法。可生物降解的聚合物纳米颗粒通常通过以下五种技术由预制聚合物制备而成：乳化 - 溶剂蒸发法、溶剂置换法、盐析法、乳化 - 溶剂扩散法和复乳溶剂蒸发法。本综述讨论了盐析技术在药物递送系统及其他制药应用开发中制备纳米颗粒的用途。总结了研究文献和专利中新型胶体药物递送制剂的相关应用、配方和释放特性。本综述旨在作为合理开发药用聚合物胶体系统的工具。
