Department of General Biochemistry, Faculty of Biophysics, Biochemistry and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Int J Mol Sci. 2020 Sep 29;21(19):7183. doi: 10.3390/ijms21197183.
Inflammation is an organism's physiological response to harmful septic and aseptic stimuli. This process begins locally through the influx of immune system cells to the damaged tissue and the subsequent activation and secretion of inflammatory mediators to restore homeostasis in the organism. Inflammation is regulated at many levels, and one of these levels is post-transcriptional regulation, which controls the half-life of transcripts that encode inflammatory mediators. One of the proteins responsible for controlling the amount of mRNA in a cell is the RNase monocyte chemoattractant protein-induced protein 1 (MCPIP1). The studies conducted so far have shown that MCPIP1 is involved not only in the regulation of inflammation but also in many other physiological and pathological processes. This paper provides a summary of the information on the role of MCPIP1 in adipogenesis, angiogenesis, cell differentiation, cancer, and skin inflammation obtained to date.
炎症是机体对有害的感染性和非感染性刺激物的生理反应。这个过程通过免疫系统细胞流入受损组织开始，随后激活和分泌炎症介质，以恢复机体的内稳态。炎症在多个水平上受到调节，其中之一是转录后调节，它控制编码炎症介质的转录本的半衰期。负责控制细胞中 mRNA 数量的蛋白质之一是核糖核酸酶单核细胞趋化蛋白诱导蛋白 1（MCPIP1）。到目前为止进行的研究表明，MCPIP1 不仅参与炎症的调节，还参与许多其他生理和病理过程。本文总结了迄今为止获得的关于 MCPIP1 在脂肪生成、血管生成、细胞分化、癌症和皮肤炎症中的作用的信息。
