Bu Siyuan, Lv Yihan, Liu Yusheng, Qiao Sen, Wang Hongmei
Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.
Department of Pharmacology, Center for Molecular Signaling (PZMS), School of Medicine, Saarland University, Homburg, Germany.
Front Neurosci. 2021 Nov 18;15:760567. doi: 10.3389/fnins.2021.760567. eCollection 2021.
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases. The purpose of this review is to summarize the types and roles of ZNF in neuropsychiatric disorders. We will describe the structure and classification of ZNF, then focus on the pathophysiological role of ZNF in neuro-related diseases and summarize the mechanism of action of ZNF in neuro-related diseases.
锌指蛋白（ZNF）是真核生物基因组中最为丰富的蛋白质之一。它含有多个锌指结构域，这些结构域能够选择性地结合特定的DNA或RNA，并与蛋白质相互作用，因此，锌指蛋白可以在转录和翻译水平上调节基因表达。就神经疾病而言，大量研究表明许多锌指蛋白与神经疾病有关。本综述的目的是总结锌指蛋白在神经精神疾病中的类型和作用。我们将描述锌指蛋白的结构和分类，然后重点关注锌指蛋白在神经相关疾病中的病理生理作用，并总结锌指蛋白在神经相关疾病中的作用机制。
