The c.*52 and c.*773 Genetic Variants in the UTR'3 of the Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration.

Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three gene polymorphisms located in the region (c.*52 , c.504 , and c. 773 ) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the allele of the polymorphism was associated with a higher risk of ACS (OR = 2.02, = 0.033, and OR = 2.00, = 0.009, respectively). In the same way, under co-dominant and recessive models, the allele of the polymorphism was associated with a high risk of ACS (OR = 2.04, = 0.027, and OR = 2.01, = 0.007, respectively). The " haplotype was associated with a high risk of ACS (OR = 1.22, = 0.016). The genotype showed a lower HDL-C concentration than individuals with the genotype. In addition, carriers of genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the genotype. Our data suggest the association of the and polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population.