Medical School, Hangzhou Normal University, Hangzhou 310000, China.
Medical School, Shihezi University, Shihezi 832000, China.
Int J Environ Res Public Health. 2019 Sep 2;16(17):3207. doi: 10.3390/ijerph16173207.
Unfavorable serum lipid levels are the most important risk factors for coronary artery disease (CAD), cerebral infarction, and other cardiovascular and cerebrovascular diseases. This study included 2323 Han Chinese in southern China. We collected medical reports, lifestyle details, and blood samples of individuals and used the polymerase chain reaction-ligase detection reaction method to genotype single-nucleotide polymorphisms (SNPs). Two SNPs showed a strong evidence of association with total cholesterol (TC): rs1003723 and rs6413504 in the low-density lipoproteins receptor (). Two SNPs in showed a strong evidence of association with low-density lipoprotein cholesterol (LDL-C), rs1003723 and rs6413504. Two SNPs showed a strong evidence of association with triglycerides (TG), namely, rs662145 in pro-protein convertase subtilisin-kexin type 9 ( and rs11643718 in the solute carrier family 12 member 3 (. For the TC, LDL-C, and TG levels, these SNPs generated strong combined effects on these lipid levels. For each additional dangerous gene, TC increased by 0.085 mmol/L ( = 7.00 × 10), and LDL-C increased by 0.075 mmol/L ( = 9.00 × 10). The TG increased by 0.096 mmol/L ( = 2.90 × 10). Compared with those bearing no risk alleles, the risk of hypertriglyceridemia, hypercholesterolemia, and dyslipidemia increased in those with two or more risk alleles and one risk gene. Polymorphisms of , , and were associated with the plasma lipid levels in people in southern China. These results provide a theoretical basis for gene screening and the prevention of dyslipidemia.
血脂水平异常是冠心病（CAD）、脑梗死等心脑血管疾病最重要的危险因素。本研究纳入了中国南方 2323 例汉族人群。我们收集了个体的医疗报告、生活方式细节和血液样本，并使用聚合酶链反应-连接酶检测反应方法对单核苷酸多态性（SNPs）进行基因分型。两个 SNP 与总胆固醇（TC）呈强关联：低密度脂蛋白受体（）中的 rs1003723 和 rs6413504。 中的两个 SNP 与低密度脂蛋白胆固醇（LDL-C）呈强关联，即 rs1003723 和 rs6413504。两个 SNP 与甘油三酯（TG）呈强关联，即前蛋白转化酶枯草溶菌素/kexin 9 型（中的 rs662145 和溶质载体家族 12 成员 3 （中的 rs11643718。对于 TC、LDL-C 和 TG 水平，这些 SNP 对这些脂质水平产生了强烈的综合影响。对于每个额外的危险基因，TC 增加 0.085mmol/L（=7.00×10），LDL-C 增加 0.075mmol/L（=9.00×10）。TG 增加 0.096mmol/L（=2.90×10）。与不携带危险等位基因的个体相比，携带两个或更多危险等位基因和一个危险基因的个体发生高甘油三酯血症、高胆固醇血症和血脂异常的风险增加。 、 和 的多态性与中国南方人群的血浆血脂水平相关。这些结果为基因筛选和血脂异常的预防提供了理论依据。
