Landy H J, Isada N B, Larsen J W
Am J Obstet Gynecol. 1987 Jul;157(1):114-7. doi: 10.1016/s0002-9378(87)80358-7.
The antenatal diagnosis of hydramnios requires a careful search for associated underlying maternal or fetal conditions. Even in pregnancies associated with idiopathic hydramnios in which no underlying condition can be identified, a high perinatal mortality rate exists. Although trisomy 18 has been seen in pregnancies with hydramnios and growth retardation, the association with specific chromosomal disorders and idiopathic hydramnios has not been well defined. A review of pregnancies complicated by hydramnios was undertaken; 99 cases with complete pregnancy and delivery information were identified. Fifty-nine pregnancies were complicated by idiopathic hydramnios, and except for the hydramnios, sonographic evaluation was normal. Delivery information revealed one infant with trisomy 18 and eight infants with structural anomalies not appreciated antenatally. Of the undiagnosed malformations, 25% are frequently associated with trisomy 21. We recommend fetal chromosomal analysis as an adjunct to the evaluation of pregnancies complicated by idiopathic hydramnios.
羊水过多的产前诊断需要仔细查找相关的潜在母体或胎儿疾病。即使在与特发性羊水过多相关的妊娠中，无法确定潜在疾病，围产期死亡率也很高。虽然18三体在羊水过多和生长受限的妊娠中可见，但与特定染色体疾病和特发性羊水过多的关联尚未明确界定。对并发羊水过多的妊娠进行了回顾；确定了99例有完整妊娠和分娩信息的病例。59例妊娠并发特发性羊水过多，除羊水过多外，超声评估正常。分娩信息显示1例婴儿患有18三体，8例婴儿有产前未发现的结构异常。在未诊断出的畸形中，25%常与21三体相关。我们建议对并发特发性羊水过多的妊娠进行胎儿染色体分析作为评估的辅助手段。
