Li Qinyang, Hu Yao, Zhou Xuedong, Liu Shiyu, Han Qi, Cheng Lei
State Key Laboratory of Oral Diseases & West China School of Stomatology & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China.
Cancers (Basel). 2020 Sep 29;12(10):2797. doi: 10.3390/cancers12102797.
Oral squamous cell carcinoma (OSCC) is an invasive epithelial neoplasm that is influenced by various risk factors, with a low survival rate and an increasing death rate. In the past few years, with the verification of the close relationship between different types of cancers and the microbiome, research has focused on the compositional changes of oral bacteria and their role in OSCC. Generally, oral bacteria can participate in OSCC development by promoting cell proliferation and angiogenesis, influencing normal apoptosis, facilitating invasion and metastasis, and assisting cancer stem cells. The study findings on the association between oral bacteria and OSCC may provide new insight into methods for early diagnosis and treatment development.
口腔鳞状细胞癌（OSCC）是一种侵袭性上皮肿瘤，受多种风险因素影响，生存率低且死亡率不断上升。在过去几年中，随着不同类型癌症与微生物群之间密切关系的证实，研究聚焦于口腔细菌的组成变化及其在OSCC中的作用。一般来说，口腔细菌可通过促进细胞增殖和血管生成、影响正常细胞凋亡、促进侵袭和转移以及辅助癌症干细胞来参与OSCC的发展。关于口腔细菌与OSCC关联的研究结果可能为早期诊断方法和治疗开发提供新的见解。
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