Rao N Vijayakameswara, Rho Jun Gi, Um Wooram, Ek Pramod Kumar, Nguyen Van Quy, Oh Byeong Hoon, Kim Wook, Park Jae Hyung
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea.
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10617, Taiwan.
Pharmaceutics. 2020 Sep 29;12(10):931. doi: 10.3390/pharmaceutics12100931.
Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.
由于其独特的生物学功能，透明质酸（HA）及其衍生物已被广泛探索用于生物医学应用，如组织工程、药物递送和分子成像。特别是，自组装透明质酸纳米颗粒（HA-NPs）已被广泛用作靶向特异性和长效纳米载体，用于递送各种治疗或诊断剂。最近，已经证明不携带任何治疗剂的空HA-NPs可通过调节炎症反应用于炎症性疾病的治疗。在这篇综述中，我们旨在概述该领域的重大成就，并强调HA-NPs在治疗炎症性疾病方面的潜力。
