The Department of Biosciences and Nutrition, Stockholm University, 17177 Stockholm, Sweden.
Biomedical Library, Gothenburg University Library, University of Gothenburg, 40530 Gothenburg, Sweden.
Nutrients. 2020 Sep 29;12(10):2991. doi: 10.3390/nu12102991.
The aim was to compile the evidence from Randomized Controlled Trials (RCTs) of diet or dietary supplements used to reduce disease activity in adults with Rheumatoid Arthritis (RA). Searches were performed in the databases PubMed, Scopus and Cochrane. Only RCT studies of diets, foods or dietary supplements, looking at effects on the Disease Activity Score in 28 joints (DAS28) among adults with RA, published in peer-reviewed journals, were included. A total of 27 articles were included-three of whole diets (Mediterranean diet, raw food and anti-inflammatory diet), five of food items, five of n-3 fatty acids, five of single micronutrient supplements, four of single antioxidant supplements and five of pre-, pro- or synbiotics. Studies that showed moderate strength evidence for positive effects on disease activity in RA included interventions with a Mediterranean diet, spices (ginger powder, cinnamon powder, saffron), antioxidants (quercetin and ubiquinone), and probiotics containing Lactobacillus Casei. Other diets or supplements had either no effects or low to very low strength of evidence. In conclusion, RCT studies on diet or dietary supplements are limited in patients with RA, but based on the results in this review there is evidence that some interventions might have positive effects on DAS28.
目的是编译随机对照试验（RCT）的证据，这些试验使用饮食或膳食补充剂来降低类风湿关节炎（RA）成人的疾病活动度。在 PubMed、Scopus 和 Cochrane 数据库中进行了检索。仅纳入了在同行评议期刊上发表的 RCT 研究，这些研究着眼于饮食、食物或膳食补充剂对 RA 成人的 28 个关节疾病活动评分（DAS28）的影响。共纳入了 27 篇文章——其中 3 篇是全饮食（地中海饮食、生食和抗炎饮食），5 篇是食物项目，5 篇是 n-3 脂肪酸，5 篇是单一微量营养素补充剂，4 篇是单一抗氧化剂补充剂，5 篇是前、益生菌或合生元。对于 RA 疾病活动具有中度强度证据的积极影响的研究包括采用地中海饮食、香料（姜粉、肉桂粉、藏红花）、抗氧化剂（槲皮素和泛醌）和含有干酪乳杆菌的益生菌的干预措施。其他饮食或补充剂要么没有效果，要么证据的强度低至非常低。总之，关于饮食或膳食补充剂的 RCT 研究在 RA 患者中是有限的，但基于本综述的结果，有证据表明某些干预措施可能对 DAS28 有积极影响。
