Lin Tianqiong, Xu Zehong, Chen Jiali, Wang Xiaoyu, Li Qiaoping, Ye Biying, Hu Chaoyan
Department of Nursing, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Rheumatology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Microbiol. 2025 Jul 16;16:1589331. doi: 10.3389/fmicb.2025.1589331. eCollection 2025.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown etiology. Recent studies have indicated a potential relationship between the oral microbiome and the onset and progression of RA. However, research trends in this area have not been comprehensively examined. The aim of this study was to conduct a bibliometric analysis of the relationship between RA and the oral microbiome from January 1, 1995, to January 10, 2024, to elucidate the research landscape, including hot topics and emerging trends.
We extracted literature related to RA and the oral microbiome from the Web of Science database. Utilizing CiteSpace software, we analyzed publications, countries, institutions, authors, and keywords through a visual knowledge graph to assess research hotspots and trends.
In total, 833 articles were identified, revealing a consistent increase in the number of annual publications in this field over the study period. The United States has emerged as the leading country in terms of publication volume, with Harvard University being the most prolific institution. Among the authors, Jan Potempa has the highest number of publications. Keyword analysis indicated that current research hotspots concerning the relationship between RA and the oral microbiome primarily focus on , periodontitis, inflammation, expression, and peptidylarginine deiminase. Investigating the mechanisms by which oral and intestinal microorganisms influence RA, as well as developing intervention strategies targeting these microbiotas, is anticipated to be a significant future research direction.
This study characterized the trends in the literature regarding the relationship between RA and the oral microbiome, providing valuable insights for scholars pursuing further research.
类风湿性关节炎（RA）是一种病因不明的慢性全身性自身免疫性疾病。最近的研究表明口腔微生物群与RA的发病和进展之间存在潜在关系。然而，该领域的研究趋势尚未得到全面审视。本研究的目的是对1995年1月1日至2024年1月10日期间RA与口腔微生物群之间的关系进行文献计量分析，以阐明研究概况，包括热点话题和新趋势。
我们从科学网数据库中提取了与RA和口腔微生物群相关的文献。利用CiteSpace软件，我们通过可视化知识图谱分析了出版物、国家、机构、作者和关键词，以评估研究热点和趋势。
共识别出833篇文章，显示在研究期间该领域的年出版物数量持续增加。美国在出版物数量方面成为领先国家，哈佛大学是产出最多的机构。在作者中，扬·波滕帕的出版物数量最多。关键词分析表明，目前关于RA与口腔微生物群关系的研究热点主要集中在牙周炎、炎症、表达和肽基精氨酸脱氨酶。研究口腔和肠道微生物影响RA的机制，以及制定针对这些微生物群的干预策略，预计将成为未来一个重要的研究方向。
本研究描述了关于RA与口腔微生物群关系的文献趋势，为从事进一步研究的学者提供了有价值的见解。
