School of Public Health, Health Science Center, Ningbo University, Ningbo, China.
Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Immunol. 2024 Nov 1;15:1454594. doi: 10.3389/fimmu.2024.1454594. eCollection 2024.
Our study was conducted to explore the link between oxidative balance score (OBS) and rheumatoid arthritis (RA).
A total of 21,415 participants were included in our research from five cycles (2011-2012, 2013-2014, 2015-2016, 2017-2018, and 2017-2020) of the National Health and Nutrition Examination Survey (NHANES). Moreover, 20 elements related to diet as well as lifestyle were combined to calculate OBS. The relationship between OBS and RA was assessed by employing multivariable regression analysis, and further exploration was carried out through subgroup analysis, restricted cubic spline analysis, and sensitivity analysis. Multiple covariates were selected to adjust the model for more robust results.
In our cross-sectional study, a higher OBS has a protective effect on the development of RA (OR = 0.98, 95% CI: 0.97 to 0.99). In contrast to individuals aged ≥60, the result is more prominent in the population aged 20-60 (OR = 0.97, 95% CI: 0.96 to 0.98). Marital status appears to introduce interference in the relationship between OBS and RA, and unmarried individuals exhibited different outcomes (OR = 1.02, 95% CI: 0.99 to 1.04) compared to others. The positive influence of OBS was more evident in patients with chronic kidney disease and cardiovascular disease, while it was stronger in individuals without diabetes and liver disease.
A higher OBS correlates with a reduced odd of RA. Further studies are needed to shoot more sights on improving dietary habits and lifestyles to gain proper OBS and explore whether OBS can be one of the measurements utilized to measure the risk of RA.
本研究旨在探讨氧化平衡评分（OBS）与类风湿关节炎（RA）之间的关系。
我们的研究纳入了来自五个周期（2011-2012 年、2013-2014 年、2015-2016 年、2017-2018 年和 2017-2020 年）的全国健康与营养调查（NHANES）的 21415 名参与者。此外，我们结合了 20 种与饮食和生活方式相关的因素来计算 OBS。采用多变量回归分析评估 OBS 与 RA 之间的关系，并通过亚组分析、限制立方样条分析和敏感性分析进行进一步探讨。选择多个协变量来调整模型，以获得更稳健的结果。
在我们的横断面研究中，较高的 OBS 对 RA 的发生具有保护作用（OR=0.98，95%CI：0.97 至 0.99）。与年龄≥60 岁的个体相比，该结果在 20-60 岁的人群中更为显著（OR=0.97，95%CI：0.96 至 0.98）。婚姻状况似乎会干扰 OBS 与 RA 之间的关系，与其他人相比，未婚个体表现出不同的结果（OR=1.02，95%CI：0.99 至 1.04）。OBS 的积极影响在患有慢性肾脏病和心血管疾病的患者中更为明显，而在没有糖尿病和肝病的患者中则更强。
较高的 OBS 与 RA 发生的几率降低相关。需要进一步研究以改善饮食习惯和生活方式以获得适当的 OBS，并探讨 OBS 是否可以作为衡量 RA 风险的指标之一。
