Louisiana State University Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA.
Tulane University School of Medicine, Department of Internal Medicine, New Orleans, LA, USA.
Best Pract Res Clin Anaesthesiol. 2020 Sep;34(3):651-662. doi: 10.1016/j.bpa.2020.07.004. Epub 2020 Jul 22.
Pharmacogenomics is the study of how genetic differences between individuals affect pharmacokinetics and pharmacodynamics. These differences are apparent to clinicians when taking into account the wide range of responses to medications given in clinical practice. A review of literature involving pharmacogenomics and pain management was performed. The implementation of preoperative pharmacogenomics will allow us to better care for our patients by delivering personalized, safer medicine. This review describes the current state of pharmacogenomics as it relates to many aspects of clinical practice and how clinicians can use these tools to improve patient outcomes.
药物基因组学是研究个体之间的遗传差异如何影响药物代谢动力学和药效动力学。当考虑到临床实践中给予的药物反应的广泛差异时，临床医生会注意到这些差异。对涉及药物基因组学和疼痛管理的文献进行了回顾。实施术前药物基因组学将使我们能够通过提供个性化、更安全的药物来更好地照顾我们的患者。这篇综述描述了药物基因组学与临床实践的许多方面的现状，以及临床医生如何使用这些工具来改善患者的治疗效果。
