Kawana Y, Sato H, Shimada H, Fujita N, Ueda Y, Hayashi A, Araki Y
Anesth Analg. 1987 Aug;66(8):735-8.
This double-blind study evaluates whether ketamine given epidurally is effective for postoperative pain relief, and compares the effects of epidural ketamine with those of epidural morphine. Sixty-eight patients undergoing abdominal gynecologic surgery were randomly assigned into six groups (control; ketamine 4, 6, and 8 mg in saline; 6 mg in 10% glucose; morphine 3 mg). All patients were anesthetized with thiopental, nitrous oxide, and enflurane, and drugs were administered epidurally at the end of the operation. The duration of analgesia in the ketamine groups did not differ from that in control patients and the difference in diluent had no observable effects. Significantly, none of the patients in the morphine group needed additional analgesics within 24 hr, whereas 85% in the other five groups did. We conclude that ketamine administered epidurally is inadequate for postoperative pain relief after gynecologic operations.
这项双盲研究评估硬膜外给予氯胺酮是否对术后疼痛缓解有效，并比较硬膜外氯胺酮与硬膜外吗啡的效果。68例行腹部妇科手术的患者被随机分为六组（对照组；生理盐水含氯胺酮4、6和8毫克；10%葡萄糖含氯胺酮6毫克；吗啡3毫克）。所有患者均用硫喷妥钠、氧化亚氮和安氟醚麻醉，药物在手术结束时硬膜外给药。氯胺酮组的镇痛持续时间与对照组患者无差异，稀释剂的差异无明显影响。值得注意的是，吗啡组中没有患者在24小时内需要额外的镇痛药，而其他五组中有85%的患者需要。我们得出结论，硬膜外给予氯胺酮对妇科手术后的疼痛缓解不足。
