From the Faculty of Psychology (E.C., F.C., C.G., S.F.C.), Institute for Advanced Studies, IUSS, Pavia; Nuclear Medicine Unit (C.P., V.B., A.P.), Department of Experimental and Clinical Biomedical Sciences, and NEUROFARBA, Department of Neuroscience, Psychology, Drug Research and Child Health (S.S.), University of Florence; Nuclear Medicine Unit (L.P., A.S., D.P.), IRCCS San Raffaele Hospital, Milan; Faculty of Psychology (V.E., A.S., D.P.), Vita-Salute San Raffaele University, Milan; Department of Neurology and INSPE (M.F., G.M.), San Raffaele Scientific Institute, Milan; Clinical Neuroscience Department (S.I.), San Raffaele Turro Hospital, Milan; IRCCS Fondazione Don Carlo Gnocchi (S.S.), Florence, and IRCCS Fondazione Istituto Neurologico Casimiro Mondino (S.F.C.), Pavia, Italy.
Neurology. 2020 Nov 17;95(20):e2816-e2830. doi: 10.1212/WNL.0000000000010967. Epub 2020 Oct 1.
To investigate the types of errors produced in a picture naming task by patients with neurodegenerative dementia due to different etiologies and their neural correlates.
The same standardized picture naming test was administered to a consecutive sample of patients (n = 148) who had been studied with [F] FDG-PET. The errors were analyzed in 3 categories (visual, semantic, and phonologic). The PET data were analyzed using an optimized single-subject procedure, and the statistical parametric mapping multiple regression design was used to explore the correlation between each type of error and brain hypometabolism in the whole group. Metabolic connectivity analyses were run at the group level on 7 left hemisphere cortical areas corresponding to an a priori defined naming network.
Semantic errors were predominant in most patients, independent of clinical diagnosis. In the whole group analysis, visual errors correlated with hypometabolism in the right inferior occipital lobe and in the left middle occipital lobe. Semantic errors correlated with hypometabolism in the left fusiform gyrus, the inferior and middle temporal gyri, and the temporal pole. Phonologic errors were associated with hypometabolism in the left superior and middle temporal gyri. Both positive (occipital-posterior fusiform) and negative (anterior fusiform gyrus and the superior anterior temporal lobe) connectivity changes were associated with semantic errors.
Naming errors reflect the dysfunction of separate stages of the naming process and are specific markers for different patterns of brain involvement. These correlations are not limited to primary progressive aphasia but extend to other neurodegenerative dementias.
探讨不同病因所致神经退行性痴呆患者在图片命名任务中产生的错误类型及其神经相关性。
对连续接受[F]FDG-PET 研究的 148 例患者进行了相同的标准化图片命名测试。将错误分为 3 类（视觉、语义和语音）进行分析。使用优化的单个体分析程序对 PET 数据进行分析，使用统计参数映射多元回归设计来探索每种类型的错误与全组脑代谢低下之间的相关性。在 7 个左半球皮质区域上进行组水平的代谢连通性分析，这些区域对应于预先定义的命名网络。
大多数患者以语义错误为主，与临床诊断无关。在全组分析中，视觉错误与右侧下枕叶和左侧中枕叶代谢低下相关。语义错误与左侧梭状回、颞下回和颞极代谢低下相关。语音错误与左侧中上颞叶代谢低下相关。正连接（枕叶-后梭状回）和负连接（前梭状回和前上颞叶）均与语义错误相关。
命名错误反映了命名过程中不同阶段的功能障碍，是不同脑受累模式的特异性标志物。这些相关性不仅限于原发性进行性失语症，还扩展到其他神经退行性痴呆症。
