Akhmadullina Diliara R, Konovalov Rodion N, Shpilyukova Yulia A, Fedotova Ekaterina Yu, Illarioshkin Sergey N
Research Center of Neurology, 125367 Moscow, Russia.
Brain Sci. 2023 Dec 11;13(12):1703. doi: 10.3390/brainsci13121703.
Naming decline is one of the most common symptoms of primary progressive aphasia (PPA). Most studies on anomia in PPA are performed without taking into account PPA variants, especially for action naming. Only limited data are available for the neuroanatomical basis of anomia considering differences in the pathogenesis of PPAs. The aim of our study is to investigate the associations between anomia severity for both noun and verb naming and gray matter (GM) atrophy, as well as accompanying functional connectivity (FC) changes in three PPA variants. A total of 17 patients with non-fluent (nfvPPA), 11 with semantic (svPPA), and 9 with logopenic (lvPPA) PPA variants were included in the study and underwent cognitive/naming assessments and brain MRIs. Voxel-based morphometry was performed to evaluate GM volume. A resting-state functional MRI was applied to investigate FC changes in the identified GM areas. The study shows that different brain regions are involved in naming decline in each PPA variant with a predominantly temporal lobe involvement in svPPA, parietal lobe involvement in lvPPA, and frontal lobe involvement in nfvPPA. Separate data for object and action naming in PPA variants are provided. The obtained results mainly correspond to the current understanding of language processing and indicate that the evaluation of language impairments is preferable for each PPA variant separately. A further analysis of larger cohorts of patients is necessary to confirm these preliminary results.
命名障碍是原发性进行性失语（PPA）最常见的症状之一。大多数关于PPA中命名障碍的研究在进行时未考虑PPA的不同变体，尤其是在动作命名方面。考虑到PPA发病机制的差异，关于命名障碍神经解剖学基础的可用数据有限。我们研究的目的是调查三种PPA变体中名词和动词命名的命名障碍严重程度与灰质（GM）萎缩之间的关联，以及伴随的功能连接（FC）变化。共有17例非流利型（nfvPPA）、11例语义型（svPPA）和9例音韵型（lvPPA）PPA变体患者纳入研究，并接受了认知/命名评估和脑部MRI检查。采用基于体素的形态测量法评估GM体积。应用静息态功能MRI研究已确定GM区域的FC变化。研究表明，每种PPA变体中不同的脑区参与命名障碍，svPPA主要累及颞叶，lvPPA累及顶叶，nfvPPA累及额叶。提供了PPA变体中物体和动作命名的单独数据。获得的结果主要与当前对语言处理的理解相符，并表明对每种PPA变体分别进行语言障碍评估更为可取。有必要对更大规模的患者队列进行进一步分析以证实这些初步结果。
