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血红蛋白、白蛋白、淋巴细胞、血小板评分及中性粒细胞与淋巴细胞比值是接受化疗的小细胞肺癌患者新的重要预后因素。

Hemoglobin, albumin, lymphocyte, and platelet score and neutrophil-to-lymphocyte ratio are novel significant prognostic factors for patients with small-cell lung cancer undergoing chemotherapy.

作者信息

Yang Ning, Han Xiao, Yu Jinyu, Shu Weibin, Qiu Feng, Han Junqing

机构信息

Tumor Research and Therapy Center, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.

Department of Experiment, Tumor Hospital Affiliated to Guangxi Medical University, Nanning, China.

出版信息

J Cancer Res Ther. 2020 Sep;16(5):1134-1139. doi: 10.4103/jcrt.JCRT_1066_19.

DOI:10.4103/jcrt.JCRT_1066_19

PMID:33004760

Abstract

OBJECTIVE

The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are the important prognostic markers in some tumor types. This study aimed to evaluate the prognostic impact of pretreatment using HALP, NLR, and PLR for patients with small-cell lung cancer (SCLC), who were undergoing chemotherapy.

MATERIALS AND METHODS

In this retrospective study, 335 patients with SCLC were included between 2016 and 2018. The cutoff values for HALP, NLR, and PLR were defined using X-tile software. Survival was analyzed by the Kaplan-Meier method, with differences analyzed through the log-rank test. The multivariate Cox proportional hazard model was used to evaluate the prognostic significance of HALP, NLR, and PLR for SCLC.

RESULTS

The median follow-up period was 27.1 months (range: 0.5-46.2 months). Based on the Kaplan-Meier curve analysis, it was noticed that the low pretreatment HALP (≤18.6), high pretreatment NLR (>2.4), and high PLR (>191.6) were significantly associated with worse overall survival (OS) (P = 0.009, 0.001, and 0.033, respectively). Cox multivariate analysis demonstrated that low pretreatment HALP and high pretreatment NLR were the independent prognostic factors for worse OS (hazard ratio [HR] = 1.468, 95% confidence interval [CI]: 1.004-2.146, P = 0.047; HR = 0.722, 95% CI: 0.542-0.960, P = 0.025, respectively).

CONCLUSION

HALP and NLR were the independent prognostic factors of OS for SCLC patients undergoing chemotherapy.

摘要

目的

血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）是某些肿瘤类型重要的预后标志物。本研究旨在评估HALP、NLR和PLR预处理对接受化疗的小细胞肺癌（SCLC）患者的预后影响。

材料与方法

在这项回顾性研究中，纳入了2016年至2018年间的335例SCLC患者。使用X-tile软件定义HALP、NLR和PLR的临界值。采用Kaplan-Meier法分析生存情况，通过对数秩检验分析差异。使用多变量Cox比例风险模型评估HALP、NLR和PLR对SCLC的预后意义。

结果

中位随访期为27.1个月（范围：0.5 - 46.2个月）。基于Kaplan-Meier曲线分析，发现预处理时低HALP（≤18.6）、高预处理NLR（>2.4）和高PLR（>191.6）与较差的总生存期（OS）显著相关（分别为P = 0.009、0.001和0.033）。Cox多变量分析表明，预处理时低HALP和高预处理NLR是OS较差的独立预后因素（风险比[HR] = 1.468，95%置信区间[CI]：1.004 - 2.146，P = 0.047；HR = 0.722，95% CI：0.542 - 0.960，P = 0.025）。