DITEN, University of Genoa, Via Opera Pia 11a, 16145, Genova, Italy.
Mechanical Engineering Department, University of New Mexico, Albuquerque, NM, 87131, USA.
Sci Rep. 2020 Oct 1;10(1):16336. doi: 10.1038/s41598-020-73269-9.
The presence of synchronized clusters in neuron networks is a hallmark of information transmission and processing. Common approaches to study cluster synchronization in networks of coupled oscillators ground on simplifying assumptions, which often neglect key biological features of neuron networks. Here we propose a general framework to study presence and stability of synchronous clusters in more realistic models of neuron networks, characterized by the presence of delays, different kinds of neurons and synapses. Application of this framework to two examples with different size and features (the directed network of the macaque cerebral cortex and the swim central pattern generator of a mollusc) provides an interpretation key to explain known functional mechanisms emerging from the combination of anatomy and neuron dynamics. The cluster synchronization analysis is carried out also by changing parameters and studying bifurcations. Despite some modeling simplifications in one of the examples, the obtained results are in good agreement with previously reported biological data.
神经元网络中同步簇的存在是信息传输和处理的标志。研究耦合振荡器网络中簇同步的常用方法基于简化假设,这些假设往往忽略了神经元网络的关键生物学特征。在这里,我们提出了一个通用框架来研究更现实的神经元网络模型中同步簇的存在和稳定性,这些模型的特点是存在延迟、不同类型的神经元和突触。将该框架应用于两个具有不同大小和特征的示例(猕猴大脑皮层的有向网络和软体动物的游泳中央模式发生器),为解释从解剖结构和神经元动力学组合中出现的已知功能机制提供了关键解释。通过改变参数和研究分岔,也对簇同步进行了分析。尽管其中一个示例存在一些建模简化,但得到的结果与之前报道的生物学数据非常吻合。