[Effect of antibiotics on Candida adhesion to epitheliocytes].

Tetracycline hydrochloride, a broad spectrum antibiotic was studied with respect to its effect on Candida adhesion to epitheliocytes of the oral mucosa. The experiments on mice showed that administration of 0.1 per cent solution of the antibiotic to the animals for 4 days resulted in increasing the adhesive number (AN) and adhesion index (AI) up to 175 and 250 per cent respectively as compared to the control. After 3 weeks of the antibiotic use the AN and AI amounted to 220 and 350 per cent respectively as compared to the control.