Yu Liangzhu, Li Mincai
Hubei Key Laboratory of Cardiovascular, Cerebrovascular and Metabolic Disorders, Xianning, Hubei 437100, P.R. China.
Departments of Physiology, School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Exp Ther Med. 2020 Dec;20(6):124. doi: 10.3892/etm.2020.9252. Epub 2020 Sep 24.
Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho may act as an inhibitor of vascular calcification through direct effects on vascular stem/progenitor cells with osteogenic differentiation potential. A better understanding of the possible effects of klotho on vascular stem/progenitor cells may provide novel insight into the cellular and molecular mechanisms of klotho deficiency-related vascular calcification and disease. The klotho protein may be considered as a promising therapeutic agent for treating vascular calcification and disease and calcification-related vascular diseases.
血管钙化的特征是磷酸钙在血管壁中活跃沉积，常见于衰老、糖尿病和慢性肾病。这一过程由包括血管干/祖细胞在内的不同细胞类型介导。抗衰老蛋白α-klotho可能通过直接作用于具有成骨分化潜能的血管干/祖细胞，从而作为血管钙化的抑制剂。更好地了解α-klotho对血管干/祖细胞的潜在影响，可能为α-klotho缺乏相关血管钙化和疾病的细胞及分子机制提供新的见解。α-klotho蛋白可被视为治疗血管钙化、疾病及钙化相关血管疾病的一种有前景的治疗药物。
