吩噻嗪类药物对医学上重要酵母菌的活性。
Activity of phenothiazines against medically important yeasts.
作者信息
Eilam Y, Polacheck I, Ben-Gigi G, Chernichovsky D
出版信息
Antimicrob Agents Chemother. 1987 May;31(5):834-6. doi: 10.1128/AAC.31.5.834.
Abstract
Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these drugs against fungal meningitis is discussed.
摘要
两种吩噻嗪化合物，即三氟拉嗪和氯丙嗪，可抑制五种最常见致病性酵母的体外生长，其最低抑菌浓度为10至40微克/毫升。每日腹腔注射三氟拉嗪（4至7毫克/千克体重）可提高经白色念珠菌或新型隐球菌实验性感染小鼠的存活率。本文讨论了这些药物在抗真菌性脑膜炎方面的潜在用途。
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