Eilam Y, Polacheck I, Ben-Gigi G, Chernichovsky D
Antimicrob Agents Chemother. 1987 May;31(5):834-6. doi: 10.1128/AAC.31.5.834.
Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these drugs against fungal meningitis is discussed.