从苜蓿根部分离出的化合物G2对医学上重要酵母的活性。
Activity of compound G2 isolated from alfalfa roots against medically important yeasts.
作者信息
Polacheck I, Zehavi U, Naim M, Levy M, Evron R
出版信息
Antimicrob Agents Chemother. 1986 Aug;30(2):290-4. doi: 10.1128/AAC.30.2.290.
Abstract
An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 micrograms/ml. Compound G2 was fungicidal at a relatively low concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 micrograms/ml). The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent in the treatment of mycotic infections.
摘要
从苜蓿根部分离出一种抗真菌剂，并进一步纯化得到一种非溶血的均质化合物（G2）。该化合物对10种具有医学重要性的酵母具有显著活性。通过琼脂稀释法和肉汤稀释法获得的最低抑菌浓度范围为3至15微克/毫升。对于所测试的9种不同酵母菌种，化合物G2在相对较低浓度下具有杀菌作用（最低杀菌浓度范围为6至24微克/毫升）。化合物G2的稳定性良好，且对多种酵母具有强大的抑制和杀菌活性，这表明经过进一步开发后，它可能作为治疗真菌感染的活性剂发挥作用。
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