从苜蓿根部分离出的化合物G2对医学上重要酵母的活性。
Activity of compound G2 isolated from alfalfa roots against medically important yeasts.
作者信息
Polacheck I, Zehavi U, Naim M, Levy M, Evron R
出版信息
Antimicrob Agents Chemother. 1986 Aug;30(2):290-4. doi: 10.1128/AAC.30.2.290.
Abstract
An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 micrograms/ml. Compound G2 was fungicidal at a relatively low concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 micrograms/ml). The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent in the treatment of mycotic infections.
摘要
从苜蓿根部分离出一种抗真菌剂，并进一步纯化得到一种非溶血的均质化合物（G2）。该化合物对10种具有医学重要性的酵母具有显著活性。通过琼脂稀释法和肉汤稀释法获得的最低抑菌浓度范围为3至15微克/毫升。对于所测试的9种不同酵母菌种，化合物G2在相对较低浓度下具有杀菌作用（最低杀菌浓度范围为6至24微克/毫升）。化合物G2的稳定性良好，且对多种酵母具有强大的抑制和杀菌活性，这表明经过进一步开发后，它可能作为治疗真菌感染的活性剂发挥作用。
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本文引用的文献
1
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Antimicrob Agents Chemother. 1980 Jul;18(1):158-63. doi: 10.1128/AAC.18.1.158.
2
[On the inhibitory activity of Polemonium saponin against fungi (author's transl)].
Pharmazie. 1981;36(2):133-4.
3
Fatal septicemia due to amphotericin B-resistant Candida lusitaniae.由耐两性霉素B的葡萄牙念珠菌引起的致死性败血症。
J Clin Microbiol. 1983 Aug;18(2):443-4. doi: 10.1128/jcm.18.2.443-444.1983.
4
Inhibition and killing of Candida albicans in vitro by five imidazoles in clinical use.
Antimicrob Agents Chemother. 1984 Apr;25(4):450-4. doi: 10.1128/AAC.25.4.450.
5
Lucerne saponins. IV. Relationship between their chemical constitution, and haemolytic and antifungal activities.
J Sci Food Agric. 1971 Apr;22(4):168-72. doi: 10.1002/jsfa.2740220404.
6
The role of antibiotics in the pathogenesis of Candidainfections.抗生素在念珠菌感染发病机制中的作用。
Am J Med. 1966 Jun;40(6):887-917. doi: 10.1016/0002-9343(66)90204-x.
7
The incidence of hospitalized cases of systemic mycotic infections.全身性真菌感染住院病例的发病率。
Sabouraudia. 1974 Mar;12(1):33-45. doi: 10.1080/00362177485380061.
8
Resistance to polyene antibiotics and correlated sterol changes in two isolates of Candida tropicalis from a patient with an amphotericin B-resistant funguria.来自一名患有两性霉素B耐药真菌尿症患者的两株热带假丝酵母菌对多烯抗生素的耐药性及相关甾醇变化
J Infect Dis. 1974 Jan;129(1):53-8. doi: 10.1093/infdis/129.1.53.
9
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Cancer Treat Rev. 1975 Jun;2(2):89-128. doi: 10.1016/s0305-7372(75)80005-3.
10
[Antimycotic behavior of monodesmosidic astrantia saponins].
Pharmazie. 1975 Feb;30(2):114.
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