培养基对BAY n 7133和酮康唑药敏试验的影响。
Influence of culture medium on susceptibility testing with BAY n 7133 and ketoconazole.
作者信息
Hoeprich P D, Merry J M
出版信息
J Clin Microbiol. 1986 Aug;24(2):269-71. doi: 10.1128/jcm.24.2.269-271.1986.
Abstract
The effect of four culture media (two complex and undefined [Sabouraud glucose and Kimmig] and two synthetic and defined [synthetic amino acid medium, fungal, and modified yeast nitrogen base]) on the activity in vitro of two newer azole compounds (BAY n 7133 and ketoconazole) was assessed with five strains each of Candida albicans, Candida parapsilosis, and Cryptococcus neoformans. Also, the nutritional adequacy of the four media was evaluated with the same 15 strains of yeastlike fungi. While the MICs of BAY n 7133 were higher in the complex media, the activity of ketoconazole was little affected. The Candida spp. grew least well and the C. neoformans grew best in yeast nitrogen base.
摘要
用白色念珠菌、近平滑念珠菌和新生隐球菌各5个菌株，评估了四种培养基（两种复杂且成分不明确的培养基[沙氏葡萄糖培养基和金米格培养基]以及两种合成且成分明确的培养基[合成氨基酸培养基、真菌培养基和改良酵母氮源培养基]）对两种新型唑类化合物（BAY n 7133和酮康唑）体外活性的影响。此外，还用这15株酵母样真菌评估了四种培养基的营养充足性。虽然BAY n 7133在复杂培养基中的最低抑菌浓度较高，但酮康唑的活性几乎未受影响。念珠菌属在酵母氮源培养基中生长最差，而新生隐球菌在该培养基中生长最好。
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