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本文引用的文献

1
Apricot Kernel Extract and Amygdalin Inhibit Urban Particulate Matter-Induced Keratoconjunctivitis Sicca.杏仁核提取物和苦杏仁苷抑制城市颗粒物诱导的干燥性角膜结膜炎。
Molecules. 2019 Feb 12;24(3):650. doi: 10.3390/molecules24030650.
2
Spatial and Temporal Trends of Number of Deaths Attributable to Ambient PM in the Korea.韩国归因于环境 PM 的死亡人数的时空趋势。
J Korean Med Sci. 2018 Jun 4;33(30):e193. doi: 10.3346/jkms.2018.33.e193. eCollection 2018 Jul 23.
3
Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo.空气污染中的城市颗粒物渗透到屏障受损的皮肤中，并在体内产生依赖于活性氧的皮肤炎症反应。
J Dermatol Sci. 2018 Apr 30. doi: 10.1016/j.jdermsci.2018.04.015.
4
Effects of environment pollution on the ocular surface.环境污染对眼表的影响。
Ocul Surf. 2018 Apr;16(2):198-205. doi: 10.1016/j.jtos.2018.03.001. Epub 2018 Mar 3.
5
Anti-Inflammatory and Anti-Apoptotic Effects of Acer Palmatum Thumb. Extract, KIOM-2015EW, in a Hyperosmolar-Stress-Induced In Vitro Dry Eye Model.拳卷槭提取物 KIOM-2015EW 对高渗应激诱导的体外干燥模型的抗炎和抗凋亡作用。
Nutrients. 2018 Feb 28;10(3):282. doi: 10.3390/nu10030282.
6
Effects of collected road dusts on cell viability, inflammatory response, and oxidative stress in cultured human corneal epithelial cells.收集的道路灰尘对培养的人角膜上皮细胞的细胞活力、炎症反应和氧化应激的影响。
Toxicol Lett. 2018 Mar 1;284:152-160. doi: 10.1016/j.toxlet.2017.12.012. Epub 2017 Dec 23.
7
A mouse dry eye model induced by topical administration of the air pollutant particulate matter 10.经空气污染物 10 经眼部局部给药诱导的小鼠干眼症模型。
Biomed Pharmacother. 2017 Dec;96:524-534. doi: 10.1016/j.biopha.2017.10.032. Epub 2017 Oct 13.
8
Airborne particulate matter (PM2.5) triggers autophagy in human corneal epithelial cell line.空气中的颗粒物（PM2.5）可触发人角膜上皮细胞系中的自噬。
Environ Pollut. 2017 Aug;227:314-322. doi: 10.1016/j.envpol.2017.04.078. Epub 2017 May 4.
9
Toxicity Research of PM Compositions In Vitro.颗粒物成分的体外毒性研究
Int J Environ Res Public Health. 2017 Feb 26;14(3):232. doi: 10.3390/ijerph14030232.
10
Ocular Surface Membrane-Associated Mucins.眼表面膜相关粘蛋白。
Ocul Surf. 2016 Jul;14(3):331-41. doi: 10.1016/j.jtos.2016.03.003. Epub 2016 May 3.

城市颗粒物对角膜和结膜上皮细胞的毒理学效应。

Toxicological effects of urban particulate matter on corneal and conjunctival epithelial cells.

作者信息

Hyun Soo-Wang, Song Su Jeong, Park Bongkyun, Lee Tae Gu, Kim Chan-Sik

机构信息

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054 Korea.

Present Address: Medicinal Evaluation Team, Bio-Center, Gyeonggido Business and Science Accelerator (GBSA), Suwon, Gyeonggi-do 16229 Korea.

出版信息

Toxicol Res. 2020 Feb 10;36(4):311-318. doi: 10.1007/s43188-019-00034-0. eCollection 2020 Oct.

DOI:10.1007/s43188-019-00034-0
PMID:33005590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7494700/
Abstract

Exposure to urban particulate matter (UPM) is a high-risk factor for various ocular surface diseases, including dry eye syndrome. However, the effects of UPM on corneal and conjunctival epithelium damage have not been fully elucidated. In this study, we investigated the toxicological effects of UPM exposure at high concentrations by using in vitro cultures. The cell viability, mucin expression, and the secreted inflammatory mediators of corneal and conjunctival epithelial cells was observed at 24 h after exposure to UPM. The progression of cell cycle was also examined by flow cytometry at 24 h after exposure to UPM. UPM reduced cell viability in a dose-dependent manner and increased cell population in S and G2 phase. The expression of mucin-1 was attenuated by UPM exposure, but that of mucin-4 was not. UPM increased interleukin (IL)-6 release and decreased IL-8 release. The intensity of 2',7'-dichlorofluorescein diacetate (DCF-DA) was highest at 4 h of UPM exposure. In conclusion, these results suggest that UPM causes the disruption of corneal and conjunctival epithelium by decreasing cell viability, altering cell cycle, disrupting mucin, and regulating inflammatory mediators.

摘要

暴露于城市颗粒物（UPM）是包括干眼症在内的各种眼表疾病的高风险因素。然而，UPM对角膜和结膜上皮损伤的影响尚未完全阐明。在本研究中，我们通过体外培养研究了高浓度UPM暴露的毒理学效应。在暴露于UPM后24小时观察角膜和结膜上皮细胞的细胞活力、黏蛋白表达和分泌的炎症介质。在暴露于UPM后24小时也通过流式细胞术检查细胞周期进程。UPM以剂量依赖方式降低细胞活力，并增加S期和G2期的细胞群体。黏蛋白-1的表达因UPM暴露而减弱，但黏蛋白-4的表达未受影响。UPM增加白细胞介素（IL）-6的释放并减少IL-8的释放。二乙酸荧光素（DCF-DA）的强度在UPM暴露4小时时最高。总之，这些结果表明，UPM通过降低细胞活力、改变细胞周期、破坏黏蛋白和调节炎症介质导致角膜和结膜上皮的破坏。